2-(Chloromethyl)-1,3-dioxolane

Basic Information

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CAS Number

2568-30-1

Molecular Formula

C4H7ClO2

Molecular Weight

122.55 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Boiling Point

158°C

Refractive Index

n20/D 1.449(lit.)

SMILES

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C1COC(O1)CCl

InChI

InChI=1S/C4H7ClO2/c5-3-4-6-1-2-7-4/h4H,1-3H2

InChIKey

IKZOMJGRWIOEDP-UHFFFAOYSA-N

LogP

0.5981

Topological Polar Surface Area

18.46 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

51.7

Safety Information

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Hazard Statement

H227 Combustible liquid
Flammable liquids

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class Comb liq Class Comb liq

Synonyms & References

English

2-(Chloromethyl)-m-dioxane
2-Chloromethyl-1,3-dioxolane
AS-17570
A817973
EN300-22286
2-(Chloromethyl)-1,3-dioxolane
2-(Chloromethyl)-1,3-dioxolane; 2-Chloromethyldioxolane; Chloroacetaldehyde ethylene glycol; NSC 319115
MFCD00043402
H10733
NSC319115
NS00027942
2568-30-1
IKZOMJGRWIOEDP-UHFFFAOYSA-
CS-0137170
Chloroacetaldehyde ethylene glycol
NSC 319115
2-Chloromethyldioxolane
C1321
2-Chloromethyl-[1,3]-dioxolane
1,3-Dioxolane, 2-(chloromethyl)-
Q-200262
InChI=1/C4H7ClO2/c5-3-4-6-1-2-7-4/h4H,1-3H2
2-Chloromethyl-1,3-dioxolane, 97%
AI3-08042
SCHEMBL2637635
NSC-319115
QR6QTL89KS
1,2-Bis(pyrrolidino)-ethane
Chloroacetaldehyde ethylene acetal
DTXSID8038809
EINECS 219-908-5

MDL Number

MFCD00043402

Customs Code

2932999099

FAQ

What are the physical and chemical properties of 2-(Chloromethyl)-1,3-dioxolane (CAS: 2568-30-1)?

2-(Chloromethyl)-1,3-dioxolane (CAS: 2568-30-1) is a colorless liquid with a molecular weight of approximately 114.03 g/mol. It has a melting point of -40°C and a boiling point of 104°C. The compound is moderately soluble in water but highly soluble in most organic solvents. It is known for its reactivity towards nucleophiles and electrophiles, making it useful in various organic synthesis reactions.

How is 2-(Chloromethyl)-1,3-dioxolane (CAS: 2568-30-1) typically synthesized?

2-(Chloromethyl)-1,3-dioxolane (CAS: 2568-30-1) can be synthesized by the reaction of 1,3-dioxolane with hydrochloric acid. The synthesis typically occurs through a nucleophilic substitution reaction, where the hydroxyl group of 1,3-dioxolane is replaced by a chlorine atom. This process can be carried out in a solvent such as methanol, with a yield of around 85%. Catalysts such as aluminum chloride are often used to increase the reaction rate and selectivity.

What industries use 2-(Chloromethyl)-1,3-dioxolane (CAS: 2568-30-1)?

2-(Chloromethyl)-1,3-dioxolane (CAS: 2568-30-1) finds applications in several industries. It is commonly used in pharmaceuticals for the synthesis of various organic compounds, in polymers for the production of specialized materials, and in sensors for detecting specific chemical compounds. Additionally, it is utilized in semiconductor manufacturing as a precursor for organic thin films.

What precautions should be taken when handling 2-(Chloromethyl)-1,3-dioxolane (CAS: 2568-30-1)?

When handling 2-(Chloromethyl)-1,3-dioxolane (CAS: 2568-30-1), it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure to vapors. Spills should be handled carefully, using absorbent materials and disposing of waste according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.