2-Chloro-N-(2,3-dimethylphenyl)acetamide

Basic Information

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CAS Number

2564-07-0

Molecular Formula

C10H12ClNO

Molecular Weight

197.67 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

135-136

SMILES

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CC1=C(C(=CC=C1)NC(=O)CCl)C

InChI

InChI=1S/C10H12ClNO/c1-7-4-3-5-9(8(7)2)12-10(13)6-11/h3-5H,6H2,1-2H3,(H,12,13)

InChIKey

UAXPAYVQIXNSHW-UHFFFAOYSA-N

LogP

2.480740000000001

Topological Polar Surface Area

29.1 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

184

Safety Information

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Hazard Statement

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

DTXSID20304597
J-509049
AKOS000266283
Acetamide, 2-chloro-N-(2,3-dimethylphenyl)-
AB01330520-02
2-chloro-N-(2,3-dimethylphenyl)acetamide
D83888
MFCD00018895
2564-07-0
AT-057/40164814
Acetamide,2-chloro-N-(2,3-dimethylphenyl)-
FT-0634368
CS-0116495
2-chloro-n-(2,3-dimethyl-phenyl)acetamide
SY079701
NSC166431
JS-202C
NSC-166431
2-Chloro-2',3'-acetoxylidide
Z56755217
2-Chloro-N-(2,3-dimethyl-phenyl)-acetamide
SCHEMBL4002461
BB 0243233
2-chloro-N-(2, 3-dimethylphenyl)acetamide
EN300-01790
NCGC00336753-01
2-Chloro-N-(2,3-dimethylphenyl)acetamide
2-CHLORO-2',3'-ACETOXYLIDIDE

MDL Number

MFCD00018895

Customs Code

2924299090

FAQ

What are the physical and chemical properties of 2-Chloro-N-(2,3-dimethylphenyl)acetamide (CAS: 2564-07-0)?

2-Chloro-N-(2,3-dimethylphenyl)acetamide has a crystalline form with a molecular weight of approximately 224.67 g/mol. It is slightly soluble in water but soluble in organic solvents like ethanol and acetone. The compound is reactive towards nucleophiles and can undergo substitution reactions. It has a pKa of around 7, indicating moderate basicity.

How is 2-Chloro-N-(2,3-dimethylphenyl)acetamide (CAS: 2564-07-0) typically synthesized?

2-Chloro-N-(2,3-dimethylphenyl)acetamide is typically synthesized via an amide coupling reaction. An aromatic chloromethyl compound reacts with acetamide in the presence of a base like sodium hydride or potassium tert-butoxide. This reaction is selective and yields high purity products with excellent yield.

What industries use 2-Chloro-N-(2,3-dimethylphenyl)acetamide (CAS: 2564-07-0)?

2-Chloro-N-(2,3-dimethylphenyl)acetamide is used in the pharmaceutical industry for the synthesis of certain drug intermediates. It also finds applications in the polymer industry as a monomer or plasticizer. Additionally, it is used in the sensor and semiconductor industries for specific chemical and electronic applications.

What precautions should be taken when handling 2-Chloro-N-(2,3-dimethylphenyl)acetamide (CAS: 2564-07-0)?

Handling 2-Chloro-N-(2,3-dimethylphenyl)acetamide requires appropriate Personal Protective Equipment (PPE) such as gloves, goggles, and a lab coat. It should be conducted in a well-ventilated environment or under a fume hood to avoid inhalation. Spills should be immediately neutralized with an appropriate base and flushed with water. Always consult the Safety Data Sheet (SDS) for detailed handling and safety information.