2-Chloro-N-(2,3-dimethylphenyl)acetamide(CAS: 2564-07-0)

2-Chloro-N-(2,3-dimethylphenyl)acetamide has a crystalline form with a molecular weight of approximately 224.67 g/mol. It is slightly soluble in water but soluble in organic solvents like ethanol and acetone. The compound is reactive towards nucleophiles and can undergo substitution reactions. It has a pKa of around 7, indicating moderate basicity.

2-Chloro-N-(2,3-dimethylphenyl)acetamide is typically synthesized via an amide coupling reaction. An aromatic chloromethyl compound reacts with acetamide in the presence of a base like sodium hydride or potassium tert-butoxide. This reaction is selective and yields high purity products with excellent yield.

2-Chloro-N-(2,3-dimethylphenyl)acetamide is used in the pharmaceutical industry for the synthesis of certain drug intermediates. It also finds applications in the polymer industry as a monomer or plasticizer. Additionally, it is used in the sensor and semiconductor industries for specific chemical and electronic applications.

Handling 2-Chloro-N-(2,3-dimethylphenyl)acetamide requires appropriate Personal Protective Equipment (PPE) such as gloves, goggles, and a lab coat. It should be conducted in a well-ventilated environment or under a fume hood to avoid inhalation. Spills should be immediately neutralized with an appropriate base and flushed with water. Always consult the Safety Data Sheet (SDS) for detailed handling and safety information.