4-Bromo-3-fluoropyridine

Basic Information

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CAS Number

2546-52-3

Molecular Formula

C5H3BrFN

Molecular Weight

175.99 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

169.2°Cat760mmHg

Density

1.707

Flash Point

56.1°C

Refractive Index

1.533

SMILES

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C1=CN=CC(=C1Br)F

InChI

InChI=1S/C5H3BrFN/c6-4-1-2-8-3-5(4)7/h1-3H

InChIKey

QBLOMVIUENUOJY-UHFFFAOYSA-N

LogP

1.9831999999999999

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

78.8

Synonyms & References

English

FT-0601284
DTXSID50382484
SCHEMBL784834
SY038188
2546-52-3
AM20051002
PB23387
QBLOMVIUENUOJY-UHFFFAOYSA-N
4-Bromo-3-fluoropyridine, AldrichCPR
4-Bromo-3-fluoropyridine
MFCD04113266
3-Fluoro-4-bromopyridine hydrochloride
BL001418
AKOS006229245
EN300-108790
PS-8598
4-Bromo-3-Fluoro Pyridine
Pyridine, 4-bromo-3-fluoro-
CS-0053855
4-bromo-3-fluoro-pyridine
4-Bromo-3-fluoropyridine HCl
3-Fluor-4-brom-pyridin
bromo-4 fluoro-3 pyridine
Pyridine,4-bromo-3-fluoro
4-Bromo-3-fluoropyridine hydrochloride
4-bromo-3-fluoropyridine

MDL Number

MFCD04113266

Customs Code

29333999

FAQ

What are the physical and chemical properties of 4-Bromo-3-fluoropyridine (CAS: 2546-52-3)?

4-Bromo-3-fluoropyridine (CAS: 2546-52-3) is a crystalline solid with a molecular weight of 226.01 g/mol. It is slightly soluble in water and more soluble in organic solvents like ethanol and acetone. It is chemically stable under normal conditions but can undergo bromination and fluorination reactions. This compound has a melting point of 163-165°C and a boiling point of 332-335°C under reduced pressure.

How is 4-Bromo-3-fluoropyridine (CAS: 2546-52-3) typically synthesized?

4-Bromo-3-fluoropyridine (CAS: 2546-52-3) is typically synthesized via bromination of 3-fluoropyridine with bromine in the presence of a Lewis acid catalyst like aluminum bromide. This process involves the substitution of a hydrogen atom on the pyridine ring with a bromine atom, followed by the removal of the fluoride ion.

What industries use 4-Bromo-3-fluoropyridine (CAS: 2546-52-3)?

4-Bromo-3-fluoropyridine (CAS: 2546-52-3) is primarily used in the pharmaceutical industry for the synthesis of drug intermediates. It also finds application in the semiconductor industry for the production of certain electronic materials. Additionally, it can be employed in the development of chemical sensors and as a precursor in the polymer industry for the creation of specialized polymers.

What precautions should be taken when handling 4-Bromo-3-fluoropyridine (CAS: 2546-52-3)?

When handling 4-Bromo-3-fluoropyridine (CAS: 2546-52-3), it is essential to use appropriate personal protective equipment (PPE), including gloves and safety goggles. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation of vapors. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. A Safety Data Sheet (SDS) should be consulted for detailed safety information and emergency response procedures.