4-Bromo-3-fluoropyridine(CAS: 2546-52-3)

4-Bromo-3-fluoropyridine (CAS: 2546-52-3) is a crystalline solid with a molecular weight of 226.01 g/mol. It is slightly soluble in water and more soluble in organic solvents like ethanol and acetone. It is chemically stable under normal conditions but can undergo bromination and fluorination reactions. This compound has a melting point of 163-165°C and a boiling point of 332-335°C under reduced pressure.

4-Bromo-3-fluoropyridine (CAS: 2546-52-3) is typically synthesized via bromination of 3-fluoropyridine with bromine in the presence of a Lewis acid catalyst like aluminum bromide. This process involves the substitution of a hydrogen atom on the pyridine ring with a bromine atom, followed by the removal of the fluoride ion.

4-Bromo-3-fluoropyridine (CAS: 2546-52-3) is primarily used in the pharmaceutical industry for the synthesis of drug intermediates. It also finds application in the semiconductor industry for the production of certain electronic materials. Additionally, it can be employed in the development of chemical sensors and as a precursor in the polymer industry for the creation of specialized polymers.

When handling 4-Bromo-3-fluoropyridine (CAS: 2546-52-3), it is essential to use appropriate personal protective equipment (PPE), including gloves and safety goggles. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation of vapors. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. A Safety Data Sheet (SDS) should be consulted for detailed safety information and emergency response procedures.