8-Chloro-3-quinolinol

Basic Information

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CAS Number

25369-39-5

Molecular Formula

C9H6ClNO

Molecular Weight

179.61 g/mol

Basic Physical Properties

SMILES

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Oc1cnc2c(Cl)cccc2c1

InChI

InChI=1S/C9H6ClNO/c10-8-3-1-2-6-4-7(12)5-11-9(6)8/h1-5,12H

InChIKey

HXDOLOXNQXOFKT-UHFFFAOYSA-N

LogP

2.5938000000000008

Topological Polar Surface Area

33.120000000000005 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

165

Synonyms & References

English

8-Chloroquinolin-3-ol
3-Quinolinol, 8-chloro-
8-Chloro-3-hydroxyquinoline
8-chloroquinolin-3-ol

MDL Number

MFCD18413757

FAQ

What are the physical and chemical properties of 8-Chloro-3-quinolinol (CAS: 25369-39-5)?

8-Chloro-3-quinolinol is a crystalline compound with a molecular weight of approximately 212.62 g/mol. It has a solubility of about 0.15 g/L in water at 25°C. Chemically, it is relatively stable but can react with strong bases and acids. The compound is known for its ability to form complexes and is used in various applications due to its reactivity.

How is 8-Chloro-3-quinolinol (CAS: 25369-39-5) typically synthesized?

8-Chloro-3-quinolinol is typically synthesized by the reaction of 3-quinolinol with thionyl chloride followed by purification steps. This process involves the substitution of the hydroxyl group with a chlorine atom, yielding the desired product with good selectivity and moderate to high yield.

What industries use 8-Chloro-3-quinolinol (CAS: 25369-39-5)?

8-Chloro-3-quinolinol finds applications in the pharmaceutical industry for the synthesis of certain drugs, as well as in the sensor industry for its use in detecting specific chemicals. It is also used in the synthesis of pigments and other organic compounds.

What precautions should be taken when handling 8-Chloro-3-quinolinol (CAS: 25369-39-5)?

When handling 8-Chloro-3-quinolinol, it is essential to use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be handled with care, and proper safety data sheets (SDS) should be consulted for detailed emergency procedures.