Compound Q&A
How is 7-Chloro-1,3-dihydro-2H-indol-2-one (CAS: 25369-33-9) typically synthesized?
Answer
7-Chloro-1,3-dihydro-2H-indol-2-one can be synthesized through the condensation of 2-chloroacetophenone with indole. The reaction requires a base like sodium hydroxide and is carried out in a solvent such as water or methanol. The yield is typically around 70-80%, and the reaction is selective towards the formation of the 2-hydroxy-3-chloroacetophenone intermediate which then cyclizes to form the target compound.
About
CAS No
25369-33-9
English Name
7-Chloro-1,3-dihydro-2H-indol-2-one
Molecular Formula
C8H6ClNO
Molecular Weight
167.6 g/mol
SMILES
C1C2=C(C(=CC=C2)Cl)NC1=O
InChIKey
FPDLUAACCNVSQA-UHFFFAOYSA-N
Last Updated: 2025-10-23 07:31
