5-(Difluoromethyl)-1,3,4-thiadiazol-2-amine

Basic Information

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CAS Number

25306-15-4

Molecular Formula

C3H3F2N3S

Molecular Weight

151.14 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Water Treatment Chemicals Disinfectants Chlorine Compounds

Basic Physical Properties

SMILES

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FC(c1nnc(s1)N)F

InChI

InChI=1S/C3H3F2N3S/c4-1(5)2-7-8-3(6)9-2/h1H,(H2,6,8)

InChIKey

NBGMELMIAOKZSD-UHFFFAOYSA-N

LogP

1.0579

Topological Polar Surface Area

51.8 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Synonyms & References

English

5-(DIFLUOROMETHYL)-2-AMINO-1,3,4-THIADIAZOL
5-(difluoromethyl)-1,3,4-thiadiazol-2-amine

MDL Number

MFCD11193512

FAQ

What are the physical and chemical properties of 5-(Difluoromethyl)-1,3,4-thiadiazol-2-amine (CAS: 25306-15-4)?

5-(Difluoromethyl)-1,3,4-thiadiazol-2-amine (CAS: 25306-15-4) is a white crystalline solid with a molecular weight of approximately 174.04 g/mol. It has limited water solubility and good solubility in organic solvents such as ethanol and acetonitrile. This compound is known for its stability and reactivity, particularly in the presence of nucleophiles and reducing agents.

How is 5-(Difluoromethyl)-1,3,4-thiadiazol-2-amine (CAS: 25306-15-4) typically synthesized?

5-(Difluoromethyl)-1,3,4-thiadiazol-2-amine is commonly synthesized via amidation of 5-(dichloromethyl)-1,3,4-thiadiazole with an amine such as methylamine. The reaction is conducted under mild conditions, and the yield is typically good. Various solvents can be used, and the reaction is often carried out in the presence of a base like sodium hydroxide to enhance the reaction rate and selectivity.

What industries use 5-(Difluoromethyl)-1,3,4-thiadiazol-2-amine (CAS: 25306-15-4)?

5-(Difluoromethyl)-1,3,4-thiadiazol-2-amine (CAS: 25306-15-4) finds applications in the pharmaceutical industry for the synthesis of bioactive molecules and as a precursor for drug intermediates. It is also used in the chemical industry for the development of novel materials, particularly in polymer and semiconductor applications, due to its unique electronic properties.

What precautions should be taken when handling 5-(Difluoromethyl)-1,3,4-thiadiazol-2-amine (CAS: 25306-15-4)?

When handling 5-(Difluoromethyl)-1,3,4-thiadiazol-2-amine (CAS: 25306-15-4), it is important to wear appropriate personal protective equipment (PPE), including gloves, safety glasses, and a lab coat. This compound should be stored in a cool, dry place away from direct sunlight. In case of spillage, it should be handled according to the Material Safety Data Sheet (MSDS) guidelines, and the area should be ventilated. Always ensure that the work is conducted in a well-ventilated fume hood to minimize exposure to airborne particles.