Ethyl 2-pyridinecarboxylate

Basic Information

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CAS Number

2524-52-9

Molecular Formula

C8H9NO2

Molecular Weight

151.17 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

2 °C

Boiling Point

240°C

Water Solubility

miscible

Refractive Index

n20/D 1.511(lit.)

SMILES

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CCOC(=O)c1ccccn1

InChI

InChI=1S/C8H9NO2/c1-2-11-8(10)7-5-3-4-6-9-7/h3-6H,2H2,1H3

InChIKey

FQYYIPZPELSLDK-UHFFFAOYSA-N

LogP

1.2583

Topological Polar Surface Area

39.19 Å²

Hydrogen Bond Donor/Acceptor

0 / 3

Complexity

136

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

Ethyl 2-picolinate
Ethyl picolinate,Ethyl pyridine-2-carboxylate
Ethyl pyridine-2-carboxylate~Picolinic acid ethyl ester
alpha-Picolinic acid ethyl ester
2-(Ethoxycarbonyl)pyridine
ETHYL PYRIDINE-2-CARBOXYLATE
ETHYL 2-PYRIDINECARBOXYLATE
2-PYRIDINECARBOXYLIC ACID ETHYL ESTER
2-PICOLINIC ACID, ETHYL ESTER
RARECHEM AL BI 0182
Ethyl picolinate
Picolinic Acid Ethyl
Picolinic Acid Ethyl Ester
2-ethyl picolinate
ethoxycarbonylpyridine
pyridine-2-carboxylic acid ethyl ester
2-Picolinic acid ethyl ester
2-Pyridinecarboxylic acid, ethyl ester
Picolinic acid, ethyl ester
FQYYIPZPELSLDK-UHFFFAOYSA-N
Pyridinecarboxylic acid, ethyl ester
Ethyl picolinate, 99%
PubChem11659
Ethyl Picolinate
Pyridine-2-carboxylic Acid Ethyl Ester
Ethyl pyridine-2-carboxylate

MDL Number

MFCD00006292

Customs Code

29333999

FAQ

What are the physical and chemical properties of Ethyl 2-pyridinecarboxylate (CAS: 2524-52-9)?

Ethyl 2-pyridinecarboxylate (CAS: 2524-52-9) is a crystalline compound with a molecular weight of approximately 145.17 g/mol. It has a solubility of 0.37 g/100 mL in water. It is moderately reactive, particularly in acidic conditions. This compound is often used in organic synthesis and has low volatility and a boiling point around 190°C.

How is Ethyl 2-pyridinecarboxylate (CAS: 2524-52-9) typically synthesized?

Ethyl 2-pyridinecarboxylate (CAS: 2524-52-9) can be synthesized via the acylation of 2-pyridinecarboxylic acid with ethyl chloroformate. The reaction is typically catalyzed by a base like triethylamine, with a yield of approximately 75-80%. This method ensures high selectivity and can be performed under mild conditions.

What industries use Ethyl 2-pyridinecarboxylate (CAS: 2524-52-9)?

Ethyl 2-pyridinecarboxylate (CAS: 2524-52-9) is primarily used in the pharmaceutical and chemical industries. It serves as a key intermediate in the synthesis of various medications and also finds applications in the production of polymers and organic solvents.

What precautions should be taken when handling Ethyl 2-pyridinecarboxylate (CAS: 2524-52-9)?

When handling Ethyl 2-pyridinecarboxylate (CAS: 2524-52-9), it is crucial to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a well-ventilated area and handled under a fume hood. In case of spillage, immediate cleanup should be performed using absorbent materials. Always consult the Safety Data Sheet (SDS) for detailed safety information.