Polyinosinic-polycytidylic acid

Basic Information

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CAS Number

24939-03-5

Molecular Formula

C19H27N7O16P2

Molecular Weight

671.4 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Insecticides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Boiling Point

851.4°C at 760 mmHg

SMILES

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C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COP(=O)(O)O)O)O

InChI

InChI=1S/C10H13N4O8P.C9H14N3O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20);1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,10-;4-,6-,7-,8-/m11/s1

InChIKey

ACEVNMQDUCOKHT-ZLOOHWKQSA-N

Complexity

1090

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H402 Harmful to aquatic life
Hazardous to the aquatic environment, acute hazard

Synonyms & References

English

AKOS040745302
{[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-6,9-dihydro-1H-purin-9-yl)oxolan-2-yl]methoxy}phosphonic acid; {[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid
AC-8822
Q7226506
DTXSID90947819
24939-03-5
Poly(I:C) (~90%)
AKOS025402393
[(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate;[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-1H-purin-9-yl)oxolan-2-yl]methyl dihydrogen phosphate
Polyinosinic acid-polycytidylic acid
Polyinosinic:polycytidylic acid copolymer
5'-Inosinic acid homopolymer-5'-cytidylic acid homopolymer complex (1_1)
Poly(I:C)
POLYCYTIDYLIC-INOSINIC ACID POTASSIUM SALT
Polyinosinic acid Polycytidylic acid
4-amino-1-(5-O-phosphonopentofuranosyl)pyrimidin-2(1H)-one - 9-(5-O-phosphonopentofuranosyl)-3,9-dihydro-6H-purin-6-one (1:1)
5'-cytidylic acid - 5'-inosinic acid (1:1)
Poly I:C
Polycytidysic acid
Poly(I+C)
POLY I-C
Poly(I:C) (VAN)
Polyinosinate:polycytidylate
Poly rI:poly rC
Polyinosinate-polycytidylate complex
Poly I:poly C
Poly C poly I
Polyinosinic-polycytidylic acid complex
Poly(I).poly(C)
Poly(rI).poly(rC)
Polyriboinosinic: polyribocytidylic acid

MDL Number

MFCD00131957

FAQ

What is Polyinosinic-polycytidylic acid (CAS: 24939-03-5)?

Polyinosinic-polycytidylic acid (Poly(I:C)), with the CAS number 24939-03-5, is a synthetic double-stranded RNA polymer. It is composed of repeating units of inosine and cytidine nucleotides and is known for its ability to mimic viral RNA. This compound is commonly used in research and has applications in immunology and biotechnology.

What are the main uses of Polyinosinic-polycytidylic acid (CAS: 24939-03-5)?

Polyinosinic-polycytidylic acid (CAS: 24939-03-5) is primarily used in pharmaceutical research as an immunostimulant. It is also employed in vaccine development, gene therapy, and as a tool in molecular biology for studying RNA interference and immune responses. Additionally, it finds use in industrial and research settings for its unique biological properties.

Is Polyinosinic-polycytidylic acid (CAS: 24939-03-5) safe?

Polyinosinic-polycytidylic acid (CAS: 24939-03-5) is generally considered safe when used in controlled research environments. However, it should be handled with care, as inhalation or ingestion may cause irritation. Safety protocols include wearing protective gear and following proper disposal guidelines to minimize exposure risks.

How should Polyinosinic-polycytidylic acid (CAS: 24939-03-5) be stored?

Polyinosinic-polycytidylic acid (CAS: 24939-03-5) should be stored at controlled room temperature (15–25°C), away from moisture and light. It is recommended to keep it in a sealed, desiccated container to maintain its stability and prevent degradation. Proper storage is essential to ensure its effectiveness and safety in research applications.