4-Amino-2-methylbenzoic acid

Basic Information

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CAS Number

2486-75-1

Molecular Formula

C8H9NO2

Molecular Weight

151.17 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Physical State

Pale-yellow to Yellow-brown Solid

Melting Point

160-165 °C

Boiling Point

377.2℃ at 760 mmHg

Density

1.254

Flash Point

159.1℃

Refractive Index

1.618

SMILES

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CC1=C(C=CC(=C1)N)C(=O)O

InChI

InChI=1S/C8H9NO2/c1-5-4-6(9)2-3-7(5)8(10)11/h2-4H,9H2,1H3,(H,10,11)

InChIKey

XRSQZFJLEPBPOZ-UHFFFAOYSA-N

LogP

1.27542

Topological Polar Surface Area

63.32000000000001 Å²

Hydrogen Bond Donor/Acceptor

3 / 3

Complexity

158

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

NSC49299
4-Amino-2-methylbenzoic acid, 95%
EN300-58860
TS-01987
AC-2912
AKOS005145866
XRSQZFJLEPBPOZ-UHFFFAOYSA-N
methyl-4-amino benzoic acid
4-Amino-o-toluic Acid
J-514337
FT-0647670
NSC 49299
BCP24561
AM20060573
SB36168
Z877640950
AE-562/43286946
2486-75-1
CS-W003296
SCHEMBL99201
Methyl-p-aminobenzoesaure
4-amino-2-methylbenzoic acid
2-methyl-4-amino-benzoic acid
CHEMBL3278339
SY003329
NSC-49299
MFCD06656133
DTXSID80287155
Benzoic acid, 4-amino-2-methyl-
4-Amino-2-methyl-benzoic acid
4-Amino-2-methylbenzoic acid

MDL Number

MFCD06656133

Customs Code

2922499990

FAQ

What are the physical and chemical properties of 4-Amino-2-methylbenzoic acid (CAS: 2486-75-1)?

4-Amino-2-methylbenzoic acid is a crystalline solid with a molecular weight of approximately 185.18 g/mol. It has a pKa of about 4.3 and is slightly soluble in water. The compound is reactive towards acids and bases, and it can undergo substitution reactions under certain conditions. It is also known for its low volatility and stability under normal laboratory conditions.

How is 4-Amino-2-methylbenzoic acid (CAS: 2486-75-1) typically synthesized?

4-Amino-2-methylbenzoic acid is typically synthesized through the condensation of 2-methylbenzoic acid with aniline in the presence of an acid catalyst, such as sulfuric acid. The reaction is conducted at elevated temperatures, and the yield is generally high, with good selectivity towards the desired product.

What industries use 4-Amino-2-methylbenzoic acid (CAS: 2486-75-1)?

4-Amino-2-methylbenzoic acid finds application in various industries, including pharmaceuticals, where it serves as a precursor for drug synthesis, and in the chemical industry, where it is used in the preparation of dyes and other organic compounds. It is also utilized in the production of certain polymers and sensors.

What precautions should be taken when handling 4-Amino-2-methylbenzoic acid (CAS: 2486-75-1)?

When handling 4-Amino-2-methylbenzoic acid, proper Personal Protective Equipment (PPE) should be worn, including gloves, goggles, and a lab coat. Ensure laboratory practices are conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbents, and the area should be rinsed thoroughly. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.