2-(2-Butyl-4-methyl-6-oxo-1-{[2'-(2H-tetrazol-5-yl)-4-biphenylyl]methyl}-1,6-dihydro-5-pyrimidinyl)-N,N-dimethylethanethioamide | CAS No. 247257-48-3
2-(2-Butyl-4-methyl-6-oxo-1-{[2'-(2H-tetrazol-5-yl)-4-biphenylyl]methyl}-1,6-dihydro-5-pyrimidinyl)-N,N-dimethylethanethioamide
Basic Information
CAS Number
247257-48-3
Molecular Formula
C27H31N7OS
Molecular Weight
501.66 g/mol
AD
Chemical Classification
Basic Physical Properties
Boiling Point
693.0±65.0°C at 760 mmHg
Safety Information
View Safety InformationGHS Hazard Pictograms
H302Hazard Statement
H302
Harmful if swallowed
Acute toxicity, oral
Acute toxicity, oral
Synonyms & References
English
- Fimasartan [INN]
- BCP11616
- AS-35179
- C27H31N7OS
- A919293
- SCHEMBL20126833
- 2-(1-((2'-(1H-Tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)-N,N-dimethylethanethioamide
- BDBM50364573
- 2-(2-Butyl-4-methyl-6-oxo-1-{[2'-(1H-tetrazol-5-yl)-4-biphenylyl]methyl}-1,6-dihydro-5-pyrimidinyl)-N,N-dimethylethanethioamide
- 2-Butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]pyrimidin-4(3H)-one
- AKOS016011331
- DTXSID80179460
- AC-30631
- L019170
- P58222188P
- FIMASARTAN [WHO-DD]
- 2-(1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)-N,N-dimethylethanethioamide
- Fimasartan (INN)
- 5-Pyrimidineethanethioamide, 2-butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
- s4975
- MFCD13194795
- 247257-48-3
- D10556
- CCG-269705
- 2-[2-butyl-4-methyl-6-oxo-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]met hyl]pyrimidin-5-yl]-N,N-dimethylethanethioamide
- ZB1816
- 2-((2-BUTYL-4-METHYL-6-OXO-1-((2'-(1H-TETRAZOL-5-YL)BIPHENYL-4-YL)METHYL)-1,6-DIHYDROPYRIMIDIN-5-YL))-N,N-DIMETHYLTHIOACETAMIDE
- BR-A-657.K
- FIMASARTAN
- Kanarb
- DB09279
MDL Number
MFCD13194795
FAQ
What are the physical and chemical properties of 2-(2-Butyl-4-methyl-6-oxo-1-{[2'-(2H-tetrazol-5-yl)-4-biphenylyl]methyl}-1,6-dihydro-5-pyrimidinyl)-N,N-dimethylethanethioamide (CAS: 247257-48-3)?
The compound has a crystalline form and a molecular weight of approximately 613.8 g/mol. It shows good solubility in organic solvents like DMSO and DMF, but is less soluble in water. Chemically, it is stable under normal conditions but can react with strong acids to form amines. It is sensitive to heat and moisture.
How is 2-(2-Butyl-4-methyl-6-oxo-1-{[2'-(2H-tetrazol-5-yl)-4-biphenylyl]methyl}-1,6-dihydro-5-pyrimidinyl)-N,N-dimethylethanethioamide (CAS: 247257-48-3) typically synthesized?
The compound is typically synthesized using a multistep process involving the coupling of pyrimidine derivatives with tetrazolyl biphenyl groups. This reaction is catalyzed by a palladium complex and requires the use of a base like triethylamine. The yield is around 70-80%, and the selectivity is excellent.
What industries use 2-(2-Butyl-4-methyl-6-oxo-1-{[2'-(2H-tetrazol-5-yl)-4-biphenylyl]methyl}-1,6-dihydro-5-pyrimidinyl)-N,N-dimethylethanethioamide (CAS: 247257-48-3)?
This compound is primarily used in the pharmaceutical industry for the development of new drugs due to its biological activity. It is also explored for its potential applications in polymers for its unique chemical properties and in sensors and semiconductors for its electronic characteristics.
What precautions should be taken when handling 2-(2-Butyl-4-methyl-6-oxo-1-{[2'-(2H-tetrazol-5-yl)-4-biphenylyl]methyl}-1,6-dihydro-5-pyrimidinyl)-N,N-dimethylethanethioamide (CAS: 247257-48-3)?
When handling this compound, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Store it in a cool, dry place away from direct sunlight. Use a fume hood when performing reactions. In case of a spill, use appropriate containment and clean up with care. Always consult the Material Safety Data Sheet (MSDS) for detailed safety information.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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