Compound Q&A
How is 2-(2-Butyl-4-methyl-6-oxo-1-{[2'-(2H-tetrazol-5-yl)-4-biphenylyl]methyl}-1,6-dihydro-5-pyrimidinyl)-N,N-dimethylethanethioamide (CAS: 247257-48-3) typically synthesized?
Answer
![2-(2-Butyl-4-methyl-6-oxo-1-{[2'-(2H-tetrazol-5-yl)-4-biphenylyl]methyl}-1,6-dihydro-5-pyrimidinyl)-N,N-dimethylethanethioamide](https://static.chemtradehub.com/structs/247/247257-48-3-33e3.webp "2-(2-Butyl-4-methyl-6-oxo-1-{[2'-(2H-tetrazol-5-yl)-4-biphenylyl]methyl}-1,6-dihydro-5-pyrimidinyl)-N,N-dimethylethanethioamide")
The compound is typically synthesized using a multistep process involving the coupling of pyrimidine derivatives with tetrazolyl biphenyl groups. This reaction is catalyzed by a palladium complex and requires the use of a base like triethylamine. The yield is around 70-80%, and the selectivity is excellent.
About
CAS No
247257-48-3
English Name
2-(2-Butyl-4-methyl-6-oxo-1-{[2'-(2H-tetrazol-5-yl)-4-biphenylyl]methyl}-1,6-dihydro-5-pyrimidinyl)-N,N-dimethylethanethioamide
Molecular Formula
C27H31N7OS
Molecular Weight
501.66 g/mol
SMILES
CCCCC1=NC(=C(C(=O)N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CC(=S)N(C)C)C
InChIKey
AMEROGPZOLAFBN-UHFFFAOYSA-N
Last Updated: 2025-10-07 19:42
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