5-chloro-3-fluoro-pyridin-2-amine

Basic Information

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CAS Number

246847-98-3

Molecular Formula

C5H4ClFN2

Molecular Weight

146.55 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

91-95 °C

Boiling Point

195.9℃ at 760 mmHg

Density

1.45

Flash Point

195.929 °C at 760 mmHg

Refractive Index

1.576

SMILES

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C1=C(C=NC(=C1F)N)Cl

InChI

InChI=1S/C5H4ClFN2/c6-3-1-4(7)5(8)9-2-3/h1-2H,(H2,8,9)

InChIKey

FPUPPVDVOFJSEP-UHFFFAOYSA-N

LogP

1.4563

Topological Polar Surface Area

38.91 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

101

Safety Information

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Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

H311 Toxic in contact with skin
Acute toxicity, dermal

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H331 Toxic if inhaled
Acute toxicity, inhalation

H400 Very toxic to aquatic life
Hazardous to the aquatic environment, acute hazard

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

SCHEMBL558930
FPUPPVDVOFJSEP-UHFFFAOYSA-N
246847-98-3
2-Amino-5-chloro-3-fluoropyridine
DTXSID70470231
RB1090
SY002648
2-Amino-3-fluoro-5-chloropyridine
AKOS005063892
CS-W010989
2-PYRIDINAMINE, 5-CHLORO-3-FLUORO-
J-507924
EN300-112155
AB53928
MFCD09878434
5-Chloro-3-fluoro-2-pyridinamine
BCP31644
AC-2717
AM62486
PS-6442
FT-0649673
5-Chloro-3-fluoro-2-pyridinamine;2-Amino-3-fluoro-5-chloropyridine
A817437
2-Amino-5-chloro-3-fluoropyridine, 97%
5-chloranyl-3-fluoranyl-pyridin-2-amine
5-chloro-3-fluoropyridin-2-amine
5-Chloro-3-fluoropyridin-2-amine
5-chloro-3-fluoro-pyridin-2-amine
PubChem9633
KSC554C5T
Jsp004931

MDL Number

MFCD09878434

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 5-chloro-3-fluoro-pyridin-2-amine (CAS: 246847-98-3)?

5-Chloro-3-fluoro-pyridin-2-amine is a crystalline solid with a molecular weight of approximately 182.01 g/mol. It has a melting point of around 110-112°C. The compound is slightly soluble in water and more soluble in common organic solvents like methanol and acetonitrile. It shows moderate reactivity, particularly towards nucleophiles and bases, and is known to undergo substitution reactions easily.

How is 5-chloro-3-fluoro-pyridin-2-amine (CAS: 246847-98-3) typically synthesized?

5-Chloro-3-fluoro-pyridin-2-amine can be synthesized via a multi-step process involving the reaction of 2-chloro-3-fluoropyridine with ammonia or an amine in the presence of a base like sodium hydride. The yield is typically around 70-80%, and the reaction is carried out under inert conditions to prevent side reactions.

What industries use 5-chloro-3-fluoro-pyridin-2-amine (CAS: 246847-98-3)?

5-Chloro-3-fluoro-pyridin-2-amine is used in various industries. It is a key intermediate in the synthesis of certain pharmaceuticals, particularly those used in the treatment of neurological and psychiatric disorders. It also finds applications in the development of sensors and other electronic devices due to its electronic properties.

What precautions should be taken when handling 5-chloro-3-fluoro-pyridin-2-amine (CAS: 246847-98-3)?

When handling 5-chloro-3-fluoro-pyridin-2-amine, it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. The substance should be handled in a well-ventilated area or a fume hood to avoid inhalation of vapors. In case of a spill, use appropriate absorbent materials and dispose of them according to local regulations. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.