5-chloro-3-fluoro-pyridin-2-amine(CAS: 246847-98-3)

5-Chloro-3-fluoro-pyridin-2-amine is a crystalline solid with a molecular weight of approximately 182.01 g/mol. It has a melting point of around 110-112°C. The compound is slightly soluble in water and more soluble in common organic solvents like methanol and acetonitrile. It shows moderate reactivity, particularly towards nucleophiles and bases, and is known to undergo substitution reactions easily.

5-Chloro-3-fluoro-pyridin-2-amine can be synthesized via a multi-step process involving the reaction of 2-chloro-3-fluoropyridine with ammonia or an amine in the presence of a base like sodium hydride. The yield is typically around 70-80%, and the reaction is carried out under inert conditions to prevent side reactions.

5-Chloro-3-fluoro-pyridin-2-amine is used in various industries. It is a key intermediate in the synthesis of certain pharmaceuticals, particularly those used in the treatment of neurological and psychiatric disorders. It also finds applications in the development of sensors and other electronic devices due to its electronic properties.

When handling 5-chloro-3-fluoro-pyridin-2-amine, it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. The substance should be handled in a well-ventilated area or a fume hood to avoid inhalation of vapors. In case of a spill, use appropriate absorbent materials and dispose of them according to local regulations. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.