5-Aminonicotinic acid

Basic Information

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CAS Number

24242-19-1

Molecular Formula

C6H6N2O2

Molecular Weight

138.13 g/mol

EINECS

625-282-8

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Physical State

Golden-brown

Melting Point

293 °C

Boiling Point

253.51°C (rough estimate)

Density

1.3471 (rough estimate)

Flash Point

217.6 °C

Refractive Index

1.5100 (estimate)

SMILES

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C1=C(C=NC=C1N)C(=O)O

InChI

InChI=1S/C6H6N2O2/c7-5-1-4(6(9)10)2-8-3-5/h1-3H,7H2,(H,9,10)

InChIKey

BYIORJAACCWFPU-UHFFFAOYSA-N

LogP

0.3620000000000001

pKa

2.36±0.10(Predicted)

Topological Polar Surface Area

76.21 Å²

Hydrogen Bond Donor/Acceptor

3 / 4

Complexity

138

Safety Information

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GHS Hazard Pictograms

H302

H315

H319

H335

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

PS-4088
MFCD00129116
Oprea1_455519
NSC605539
3-pyridinecarboxylic acid, 5-amino-
CHEMBL1491941
HMS2812K05
AKOS005458345
SMR000427796
Oprea1_384449
CHEBI:68578
SDCCGMLS-0065699.P001
5-aminopyridine-3-carboxylic acid
DTXSID70326623
5-Aminonicotinicacid
5-Amino-nicotinic acid
5-AMINO-3-PYRIDINECARBOXYLIC ACID
AC-1766
GEO-00183
W-200252
Q27137022
MLS000716463
FT-0601316
BDBM50427221
NSC-605539
PB13029
NS00014695
AM20050990
F1926-0005
CS-W002402
MLS001049162

MDL Number

MFCD00129116

EC Number

625-282-8

Customs Code

29333990

FAQ

What are the physical and chemical properties of 5-Aminonicotinic acid (CAS: 24242-19-1)?

5-Aminonicotinic acid (CAS: 24242-19-1) is a crystalline solid with a molecular weight of approximately 136.14 g/mol. It has a melting point of 236-238°C and is slightly soluble in water (0.2 g/100 mL at 20°C). Chemically, it is stable under normal conditions but can react with strong oxidizing agents. Its solubility increases with temperature and it forms coordination complexes with metal ions.

How is 5-Aminonicotinic acid (CAS: 24242-19-1) typically synthesized?

5-Aminonicotinic acid can be synthesized through the reduction of nicotinic acid with sodium borohydride in a polar aprotic solvent like dimethyl sulfoxide (DMSO). The reaction is catalyzed by sodium borohydride, and the yield can reach up to 85%. Other methods include the use of hydrogenation in the presence of palladium catalysts.

What industries use 5-Aminonicotinic acid (CAS: 24242-19-1)?

5-Aminonicotinic acid is used in various industries. In pharmaceuticals, it serves as an intermediate in the synthesis of drugs. It is also utilized in the production of polymers for their special properties. Additionally, it finds application in the development of sensors and as a component in semiconductors due to its electronic behavior.

What precautions should be taken when handling 5-Aminonicotinic acid (CAS: 24242-19-1)?

When handling 5-Aminonicotinic acid (CAS: 24242-19-1), it is essential to wear personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be done in a well-ventilated area or a fume hood to avoid inhalation. Spills should be cleaned up using appropriate absorbents and the area should be thoroughly washed with water. Always refer to the Safety Data Sheet (SDS) for detailed handling procedures and emergency response information.