5-Aminonicotinic acid(CAS: 24242-19-1)

5-Aminonicotinic acid (CAS: 24242-19-1) is a crystalline solid with a molecular weight of approximately 136.14 g/mol. It has a melting point of 236-238°C and is slightly soluble in water (0.2 g/100 mL at 20°C). Chemically, it is stable under normal conditions but can react with strong oxidizing agents. Its solubility increases with temperature and it forms coordination complexes with metal ions.

5-Aminonicotinic acid can be synthesized through the reduction of nicotinic acid with sodium borohydride in a polar aprotic solvent like dimethyl sulfoxide (DMSO). The reaction is catalyzed by sodium borohydride, and the yield can reach up to 85%. Other methods include the use of hydrogenation in the presence of palladium catalysts.

5-Aminonicotinic acid is used in various industries. In pharmaceuticals, it serves as an intermediate in the synthesis of drugs. It is also utilized in the production of polymers for their special properties. Additionally, it finds application in the development of sensors and as a component in semiconductors due to its electronic behavior.

When handling 5-Aminonicotinic acid (CAS: 24242-19-1), it is essential to wear personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be done in a well-ventilated area or a fume hood to avoid inhalation. Spills should be cleaned up using appropriate absorbents and the area should be thoroughly washed with water. Always refer to the Safety Data Sheet (SDS) for detailed handling procedures and emergency response information.