(3R)-3-Methylpyrrolidine hydrochloride (1:1)

Basic Information

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CAS Number

235093-98-8

Molecular Formula

C5H12ClN

Molecular Weight

121.61 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Physical State

White to Yellow Solid

SMILES

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CC1CCNC1.Cl

InChI

InChI=1S/C5H11N.ClH/c1-5-2-3-6-4-5;/h5-6H,2-4H2,1H3;1H/t5-;/m1./s1

InChIKey

JDJFUMBJQINVKP-NUBCRITNSA-N

LogP

1.0376

Topological Polar Surface Area

12.03 Å²

Hydrogen Bond Donor/Acceptor

1 / 1

Complexity

43.2

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

DTXSID60660806
(R)-3-methyl pyrrolidine hydrochloride
(R)-3-methylpyrrolidine hydrochloride
(R)-3-methyl-pyrrolidine hydrochloride, AldrichCPR
(R)-3-Methyl-pyrrolidine hydrochloride
AMY37511
PYRROLIDINE, 3-METHYL-, HYDROCHLORIDE (1:1), (3R)-
(R)-3-methylpyrrolidine HCl
235093-98-8
MFCD06796631
(3R)-3-Methylpyrrolidine--hydrogen chloride (1/1)
(R)-3-Methyl-pyrrolidine, HCl
(3R)-3-METHYLPYRROLIDINE HYDROCHLORIDE
(3R)-3-methylpyrrolidine;hydrochloride
(R)-3-Methyl-pyrrolidine HCl
A857598
EN300-754654
A4920
(R)-3-methylpyrrolidinehydrochloride
(3R)-3-Methylpyrrolidine HCl
AS-39043
Q-102189
SCHEMBL14343424
CS-0044082
AKOS015844294
(R)-3-Methylpyrrolidine hydrochloride
C5H12ClN
Pyrrolidine, 3-methyl-,hydrochloride (1:1), (3R)-
AB29518
ACT09361
ANW-53668

MDL Number

MFCD06796631

FAQ

What are the physical and chemical properties of (3R)-3-Methylpyrrolidine hydrochloride (CAS: 235093-98-8)?

(3R)-3-Methylpyrrolidine hydrochloride (CAS: 235093-98-8) is a white crystalline solid with a molecular weight of 132.65 g/mol. It has a solubility of 10.1 g/100 mL in water at 25°C. This compound is slightly acidic and shows basic properties in aqueous solution. It is less reactive compared to other amines, showing limited reactivity with carbonyl compounds but good reactivity with aldehydes and ketones under certain conditions. It is also known for its use in pharmaceutical applications and as a chiral building block in organic synthesis.

How is (3R)-3-Methylpyrrolidine hydrochloride (CAS: 235093-98-8) typically synthesized?

(3R)-3-Methylpyrrolidine hydrochloride can be synthesized via the homologation of pyrrolidine by a methylating agent such as methyl iodide in the presence of an acid catalyst. Alternatively, it can be prepared by the reduction of 3-methylpyrrolidinone with sodium borohydride. The reaction yields are typically around 70-80%, and the product can be isolated by recrystallization from water or ethanol. This compound is often used in the pharmaceutical industry and for the synthesis of chiral compounds.

What industries use (3R)-3-Methylpyrrolidine hydrochloride (CAS: 235093-98-8)?

(3R)-3-Methylpyrrolidine hydrochloride is primarily used in the pharmaceutical and chemical industries. It serves as a chiral auxiliary in the synthesis of enantiomerically pure compounds, which are essential for the development of new drug candidates. Additionally, it has applications in the production of polymers and as a sensor material in chemical sensing devices. Its use in semiconductors is less common but is explored in certain niche applications.

What precautions should be taken when handling (3R)-3-Methylpyrrolidine hydrochloride (CAS: 235093-98-8)?

When handling (3R)-3-Methylpyrrolidine hydrochloride (CAS: 235093-98-8), ensure that you wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. This compound should be handled in a well-ventilated area or a fume hood to minimize exposure to fumes. Spills should be cleaned up using absorbent materials and disposed of according to local regulations. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures. Due to its hygroscopic nature, it should be stored in a dry, sealed container away from direct sunlight and heat sources.