How is (3R)-3-Methylpyrrolidine hydrochloride (CAS: 235093-98-8) typically synthesized?

(3R)-3-Methylpyrrolidine hydrochloride can be synthesized via the homologation of pyrrolidine by a methylating agent such as methyl iodide in the presence of an acid catalyst. Alternatively, it can be prepared by the reduction of 3-methylpyrrolidinone with sodium borohydride. The reaction yields are typically around 70-80%, and the product can be isolated by recrystallization from water or ethanol. This compound is often used in the pharmaceutical industry and for the synthesis of chiral compounds.