Lapatinib Impurity 9

Basic Information

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CAS Number

231278-84-5

Molecular Formula

C26H17ClFN3O3

Molecular Weight

473.9 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Aldehydes

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

Powder

Melting Point

227.0 to 231.0 deg-C

Boiling Point

650.3°C at 760 mmHg

SMILES

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C1=CC(=CC(=C1)F)COC2=C(C=C(C=C2)NC3=NC=NC4=C3C=C(C=C4)C5=CC=C(O5)C=O)Cl

InChI

InChI=1S/C26H17ClFN3O3/c27-22-12-19(5-8-25(22)33-14-16-2-1-3-18(28)10-16)31-26-21-11-17(4-7-23(21)29-15-30-26)24-9-6-20(13-32)34-24/h1-13,15H,14H2,(H,29,30,31)

InChIKey

XQPZOUAAXRXPAM-UHFFFAOYSA-N

LogP

6.89040

Complexity

675

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

AKOS015888618
5-(4-(4-(3-fluorobenzyloxy)-3-chlorophenylamino)quinazolin-6-yl)furan-2-carbaldehyde
C2786
5-(4-(4-(3-fluorobenzyloxy)-3-chloroanilino)-6-quinazolinyl)furan-2-formaldehyde
DTXSID00457833
5-(4-(3-Chloro-4-(3-fluorobenzyloxy)-anilino)-6-quinazolinyl)furan-2-carboxaldehyde
CS-0100421
FT-0659647
2-Furancarboxaldehyde, 5-[4-[[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-6-quinazolinyl]-
5-[4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde
5-(4-{3-chloro-4-(3-fluorobenzyloxy)-anilino}-6-quinazol inyl)-furan-2-carbaldehyde
5-(4-{3-Chloro-4-[(3-fluorobenzyl)oxy]anilino}-6-quinazolinyl)-2-furaldehyde
5-[4-({3-chloro-4-[(3-fluorobenzyl)oxy] phenyl}amino)quinazolin-6-yl]-2-furaldehyde
5-[4-[3-Chloro-4-(3-fluorobenzyloxy)anilino]-6-quinazolinyl]furan-2-carboxaldehyde
[5-[4-[4-[(3-Fluorobenzyl)oxy]-3-chloroanilino]-6-quinazolinyl]-2-furancarboxaldehyde
5-[4-[[3-Chloro-4-[(3-fluorophenyl)methoxy]-phenyl]amino]-6-quinazolinyl]-2-furancarboxaldehyde
AC-8335
MFCD10565688
16,17-EPOXYPREGNENOLONEACETATE
(5-(4-(4-((3-Fluorobenzyl)oxy)-3-chloroanilino)-6-quinazolinyl)-2-furancarboxaldehyde
N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-formyl-2-furyl)-4-quinazolinamine
5-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)-2-furaldehyde
Lapatinib metabolite M11
A816574
CHEMBL3527095
5-(4-{3-chloro-4-(3-fluorobenzyloxy)-anilino}-6-quinazolinyl)-furan-2-carbaldehyde
AS-18220
5-[4-({3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl} amino)quinazolin-6-yl]-2-furaldehyde
SB18205
XA9X87F37H
C26H17ClFN3O3

MDL Number

MFCD10565688

FAQ

What is Lapatinib Impurity 9 (CAS: 231278-84-5)?

Lapatinib Impurity 9, with the CAS number 231278-84-5, is a known byproduct or contaminant that may arise during the synthesis of lapatinib, a tyrosine kinase inhibitor used in cancer treatment. It typically has a molecular formula of C19H20N2O4S and is characterized by its structural similarity to the active compound, though it lacks the pharmacological activity. This impurity is often identified through analytical methods such as HPLC and mass spectrometry in pharmaceutical quality control.

What are the main uses of Lapatinib Impurity 9 (CAS: 231278-84-5)?

Lapatinib Impurity 9 is primarily used in the analysis and characterization of lapatinib in pharmaceutical development and quality assurance processes. It helps in identifying potential impurities during drug manufacturing, ensuring safety and efficacy. Additionally, it serves as a reference standard for research and regulatory compliance in the pharmaceutical industry.

Is Lapatinib Impurity 9 (CAS: 231278-84-5) safe?

Lapatinib Impurity 9 is not intended for therapeutic use and is generally considered to have lower toxicity compared to lapatinib. However, as with any chemical compound, it should be handled with appropriate safety measures, such as wearing personal protective equipment (PPE), to minimize exposure risks. Safety standards for its handling are typically aligned with those for chemical impurities in pharmaceutical settings.

How should Lapatinib Impurity 9 (CAS: 231278-84-5) be stored?

Lapatinib Impurity 9 should be stored in a cool, dry, and dark place, preferably at 2-8°C. It is important to maintain low humidity and protect it from light exposure to ensure stability. The compound should be kept in a sealed container made of glass or inert material to prevent contamination and degradation over time.