N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-iodo-4-quinazolinamine

Basic Information

View in Editor

CAS Number

231278-20-9

Molecular Formula

C21H14ClFIN3O

Molecular Weight

505.72 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

Powder

Melting Point

223.0 to 227.0 deg-C

Boiling Point

581.3°C at 760 mmHg

Water Solubility

Slightly soluble in water.

SMILES

View in Editor

C1=CC(=CC(=C1)F)COC2=C(C=C(C=C2)NC3=NC=NC4=C3C=C(C=C4)I)Cl

InChI

InChI=1S/C21H14ClFIN3O/c22-18-10-16(5-7-20(18)28-11-13-2-1-3-14(23)8-13)27-21-17-9-15(24)4-6-19(17)25-12-26-21/h1-10,12H,11H2,(H,25,26,27)

InChIKey

UHFPFDMMKYQMLC-UHFFFAOYSA-N

LogP

6.349500000000003

Topological Polar Surface Area

47.04 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

504

Safety Information

View Safety Information

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Sensitiveness

Light Sensitive

Synonyms & References

English

n-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-iodoquinazolin-4-amine
N-[3-Chloro-4-(3-Fluorobenzyloxy)-Phenyl]-6-Iodoquinazolin-4-Amine
MFCD09998827
3W4KWN3L2W
[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl](6-iodoquinazolin-4-yl)amine
N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-iodo-4-quinazolinamine
4-[3-Chloro-4-(3-fluorobenzyloxy)anilino]-6-iodoquinazoline
Q-101357
4-[3-Chloro-4-(3-fluorobenzyloxy)phenylamino]-6-iodoquinazolin
UHFPFDMMKYQMLC-UHFFFAOYSA-N
6-Iodo-4-[3-chloro-4-(3-fluorobenzyloxy)anilino]quinazoline
4-[[3-Chloro-4-(3-fluorobenzyloxy)phenyl]amino]-6-iodoquinazoline
5H-Pyrrolo[3,4-d]pyrimidine,4-amino-6,7-dihydro
FT-0658071
AC-8334
N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-6-iodoquinazolin-4-amine
A816573
SB18203
N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-iodoquinazolin-4-amine
N-(3-Chloro-4-((3-fluorobenzyl)oxy)-phenyl)-6-iodoquinazolin-4-amine
4-[3-Chloro-4-(3-fluorobenzyloxy)phenylamino]-6-iodoquinazoline
SCHEMBL141514
CS-W011494
4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-iodo-
GS-3803
[3-chloro-4-(3-fluoro-benzyloxy)-phenyl]-(6-iodo-quinazolin-4-yl)-amine
231278-20-9
N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine
N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-iodo-4-quinazolinamine
N-[3-chloranyl-4-[(3-fluorophenyl)methoxy]phenyl]-6-iodanyl-quinazolin-4-amine
SY053116

MDL Number

MFCD09998827

Customs Code

2933990090

FAQ

What is N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-iodo-4-quinazolinamine (CAS: 231278-20-9)?

N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-iodo-4-quinazolinamine (CAS: 231278-20-9) is an organic compound with a complex structure featuring a quinazolinamine ring substituted with a 3-chloro-4-[(3-fluorobenzyl)oxy]phenyl group and an iodine atom. It is a white to off-white solid with limited solubility in water but may dissolve in organic solvents. The compound is primarily used in pharmaceutical research and development due to its potential biological activity.

What are the main uses of N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-iodo-4-quinazolinamine (CAS: 231278-20-9)?

N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-iodo-4-quinazolinamine (CAS: 231278-20-9) is mainly used in pharmaceutical research as an intermediate for developing antineoplastic agents and other therapeutic drugs. Its quinazolinamine scaffold is relevant in drug discovery targeting kinase pathways. It may also find applications in chemical synthesis and specialty industries requiring halogenated aromatic compounds.

Is N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-iodo-4-quinazolinamine (CAS: 231278-20-9) safe?

Safety of N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-iodo-4-quinazolinamine (CAS: 231278-20-9) depends on exposure conditions. It is classified as a hazardous chemical due to its halogenated derivatives, requiring protective measures like gloves, goggles, and ventilation. Handling should follow standard chemical safety protocols, and it is not approved for use in food or consumer products. Always consult safety data sheets (SDS) for detailed guidelines.

How should N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-iodo-4-quinazolinamine (CAS: 231278-20-9) be stored?

Store N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-iodo-4-quinazolinamine (CAS: 231278-20-9) in a sealed, airtight container at room temperature (≤25°C) and low humidity (≤60%). Protect from light by keeping it in a dark location. Avoid exposure to moisture and heat to maintain stability. Regularly check for degradation and follow proper chemical storage standards.