Lapatinib | CAS No. 231277-92-2

Lapatinib

Basic Information

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CAS Number

231277-92-2

Molecular Formula

C29H26ClFN4O4S

Molecular Weight

581.07 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

Powder

Melting Point

136-140°C

Boiling Point

750.7°C at 760 mmHg

Density

1.381

Flash Point

407.8 °C

Refractive Index

1.645

SMILES

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CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl

InChI

InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35)

InChIKey

BCFGMOOMADDAQU-UHFFFAOYSA-N

LogP

6.139100000000004

Topological Polar Surface Area

106.35000000000001 Å²

Hydrogen Bond Donor/Acceptor

2 / 8

Complexity

898

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

CCG-270133
GW-572016X
BC164610
BRD-K19687926-001-01-7
CAS-231277-92-2
1210608-87-9
SR-05000001472-1
Tox21_112505
N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methane sulphonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine
Lapatinib base- Bio-X
N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine
4-Quinazolinamine, N-(3-chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-
A25184
BDBM5445
N-(3-Chloro-4-{[(3-fluorophenyl)methyl]oxy}phenyl)-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furanyl]-4-quinazolinamine
BCPP000189
Q420323
BCP9000837
HY-50898
GSK-572016
1xkk
913989-15-8
AB01273965-02
UNII-0VUA21238F
Lapatinib free base
NCGC00167507-01
BRD-K19687926-379-02-5
GW572016
NCGC00167507-04
Lapatinib
CHEMBL554

MDL Number

MFCD09264194

Customs Code

2934999090

FAQ

What is Lapatinib (CAS: 231277-92-2)?

Lapatinib is a small molecule kinase inhibitor with the chemical formula C22H26N2O2S. It is known for its ability to inhibit the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), making it a valuable compound in cancer research and treatment. Its molecular weight is approximately 382.5 g/mol and it is typically a white to off-white solid at room temperature.

What are the main uses of Lapatinib (CAS: 231277-92-2)?

Lapatinib is primarily used in the treatment of certain types of breast cancer, particularly those that are resistant to other HER2-targeted therapies. It is also utilized in pharmaceutical research for its anti-cancer properties and as a tool for studying EGFR and HER2 signaling pathways. In industrial applications, it may be used as a chemical intermediate or in drug development processes.

Is Lapatinib (CAS: 231277-92-2) safe?

Lapatinib is generally considered safe when used under medical supervision for its intended therapeutic purposes. However, it may cause side effects such as diarrhea, fatigue, and skin reactions. Proper safety protocols, including handling in well-ventilated areas and following regulatory guidelines, should be observed to minimize risks during storage, transportation, and use.

How should Lapatinib (CAS: 231277-92-2) be stored?

Lapatinib should be stored in a cool, dry, and dark place, preferably at a temperature between 15°C and 30°C. It is important to maintain low humidity and protect it from light exposure to ensure stability. The compound should be kept in a sealed container and stored away from incompatible materials to prevent degradation or contamination.