2,4-Difluoro-1-iodobenzene

Basic Information

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CAS Number

2265-93-2

Molecular Formula

C6H3F2I

Molecular Weight

239.99 g/mol

Chemical Classification

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

176°C

Refractive Index

n20/D 1.557(lit.)

SMILES

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C1=CC(=C(C=C1F)F)I

InChI

InChI=1S/C6H3F2I/c7-4-1-2-6(9)5(8)3-4/h1-3H

InChIKey

YKLDMAPEGQYZRT-UHFFFAOYSA-N

LogP

2.569400000000001

Topological Polar Surface Area

0.0 Å²

Hydrogen Bond Donor/Acceptor

0 / 0

Complexity

97.1

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Sensitiveness

Light Sensitive

Synonyms & References

English

SY005121
2,4-Difluoro-1-iodobenzene
NSC 68264
CS-W010293
DTXSID70177192
2,4-Difluoroiodobenzene
Benzene, 2,4-difluoro-1-iodo-
2,4-difluoro iodobenzene
SCHEMBL79432
1,3-Difluoro-4-iodobenzene
2,4-Difluoroiodobenzene, 98%
Z381540726
GS-6052
A1599
MB00398
NSC-68264
2265-93-2
2,4-difluoro-1-iodo-benzene
EN300-197626
D2545
AM61429
2,4-difluoro-iodobenzene
AC-7207
NSC68264
FT-0610101
MFCD00040151
AKOS005254541
1,3-DIFLUORO-4-IODOBENZENE
2,4-Difluoro-1-iodobenze
1-iodo-2,4-difluorobenzene
2,4,6-TRICHLOROBENZOTRIFLUORIDE

MDL Number

MFCD00040151

Customs Code

2903999090

FAQ

What are the physical and chemical properties of 2,4-Difluoro-1-iodobenzene (CAS: 2265-93-2)?

2,4-Difluoro-1-iodobenzene is a crystalline solid with a molecular weight of approximately 263.01 g/mol. It is slightly soluble in water but soluble in common organic solvents like dichloromethane and acetonitrile. The compound is moderately reactive towards nucleophiles and can undergo substitution reactions. It has limited reactivity with electrophiles and is stable under normal laboratory conditions.

How is 2,4-Difluoro-1-iodobenzene (CAS: 2265-93-2) typically synthesized?

2,4-Difluoro-1-iodobenzene is typically synthesized through amination of 2,4-difluorobenzoyl chloride followed by iodination. Commonly, this involves the reaction of 2,4-difluorobenzoyl chloride with an amine, and subsequent iodination using sodium iodide in the presence of a base like sodium hydroxide. The reaction is carried out with good selectivity and moderate yield.

What industries use 2,4-Difluoro-1-iodobenzene (CAS: 2265-93-2)?

2,4-Difluoro-1-iodobenzene finds applications in the pharmaceutical industry for the synthesis of intermediates and active pharmaceutical ingredients. It is also used in the polymer industry as a monomer for certain polymerization processes. Additionally, it is utilized in the development of sensors and semiconductors for its unique electronic and physical properties.

What precautions should be taken when handling 2,4-Difluoro-1-iodobenzene (CAS: 2265-93-2)?

When handling 2,4-Difluoro-1-iodobenzene, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated environment or a fume hood to avoid inhalation. Spills should be handled carefully with absorbent materials and disposed of according to local hazardous waste regulations. Refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.