2,4-Difluoro-1-iodobenzene(CAS: 2265-93-2)

2,4-Difluoro-1-iodobenzene is a crystalline solid with a molecular weight of approximately 263.01 g/mol. It is slightly soluble in water but soluble in common organic solvents like dichloromethane and acetonitrile. The compound is moderately reactive towards nucleophiles and can undergo substitution reactions. It has limited reactivity with electrophiles and is stable under normal laboratory conditions.

2,4-Difluoro-1-iodobenzene is typically synthesized through amination of 2,4-difluorobenzoyl chloride followed by iodination. Commonly, this involves the reaction of 2,4-difluorobenzoyl chloride with an amine, and subsequent iodination using sodium iodide in the presence of a base like sodium hydroxide. The reaction is carried out with good selectivity and moderate yield.

2,4-Difluoro-1-iodobenzene finds applications in the pharmaceutical industry for the synthesis of intermediates and active pharmaceutical ingredients. It is also used in the polymer industry as a monomer for certain polymerization processes. Additionally, it is utilized in the development of sensors and semiconductors for its unique electronic and physical properties.

When handling 2,4-Difluoro-1-iodobenzene, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated environment or a fume hood to avoid inhalation. Spills should be handled carefully with absorbent materials and disposed of according to local hazardous waste regulations. Refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.