2'-O-(2-Methoxyethyl)-uridine

Basic Information

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CAS Number

223777-15-9

Molecular Formula

C12H18N2O7

Molecular Weight

302.28 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

SMILES

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COCCO[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C=CC(=O)NC1=O

InChI

InChI=1S/C12H18N2O7/c1-19-4-5-20-10-9(17)7(6-15)21-11(10)14-3-2-8(16)13-12(14)18/h2-3,7,9-11,15,17H,4-6H2,1H3,(H,13,16,18)/t7-,9-,10-,11-/m1/s1

InChIKey

XTXNROBDOKPICP-QCNRFFRDSA-N

LogP

-2.1811999999999987

Topological Polar Surface Area

123.00999999999999 Å²

Hydrogen Bond Donor/Acceptor

3 / 9

Complexity

428

Synonyms & References

English

2'-O-(2-Methoxyethyl)-uridine
2'-O-(2-Methoxyethyl)uridine
2?-O-(2-Methoxyethyl)uridine
2'-NITROBENZANILIDE
uridine, 2'-O-(2-methoxyethyl)-
2'-o-methoxyethyluridine
1311AB
AX8234524
1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)oxolan-2-yl]pyrimidine-2,4-dione

MDL Number

MFCD17215636

Customs Code

2934999090

FAQ

What are the physical and chemical properties of 2'-O-(2-Methoxyethyl)-uridine (CAS: 223777-15-9)?

2'-O-(2-Methoxyethyl)-uridine (CAS: 223777-15-9) is a white crystalline solid. Its molecular weight is approximately 317.24 g/mol. It is slightly soluble in water and ethanol. It is generally stable under normal conditions but should be stored in a dry environment to avoid hydrolysis. This compound reacts readily with strong acids and bases.

How is 2'-O-(2-Methoxyethyl)-uridine (CAS: 223777-15-9) typically synthesized?

2'-O-(2-Methoxyethyl)-uridine (CAS: 223777-15-9) is typically synthesized through a nucleoside modification reaction. The reaction involves the methylation of the uridine at the 2'-position using 2-methoxyethyl chloride in the presence of a base, such as diisopropylethylamine (DIPEA), followed by purification steps to isolate the product. This method yields high purity with good selectivity.

What industries use 2'-O-(2-Methoxyethyl)-uridine (CAS: 223777-15-9)?

2'-O-(2-Methoxyethyl)-uridine (CAS: 223777-15-9) is primarily used in the pharmaceutical industry for drug development, particularly in the field of antiviral and anticancer medications. It is also utilized in biosensor technologies and as a building block in some polymer synthesis processes.

What precautions should be taken when handling 2'-O-(2-Methoxyethyl)-uridine (CAS: 223777-15-9)?

When handling 2'-O-(2-Methoxyethyl)-uridine (CAS: 223777-15-9), it is important to wear appropriate personal protective equipment (PPE), such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated fume hood to avoid inhalation. Spills should be carefully cleaned up using appropriate absorbent materials, and any waste should be disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.