2-Iodo-5-methylpyridine

Basic Information

View in Editor

CAS Number

22282-62-8

Molecular Formula

C6H6IN

Molecular Weight

219.02 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

235.2±20.0 ºC (760 Torr),

Flash Point

96.0±21.8 ºC,

SMILES

View in Editor

CC1=CN=C(C=C1)I

InChI

InChI=1S/C6H6IN/c1-5-2-3-6(7)8-4-5/h2-4H,1H3

InChIKey

XOODLNRDHSTOQJ-UHFFFAOYSA-N

LogP

1.9946199999999998

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

74.9

Synonyms & References

English

XOODLNRDHSTOQJ-UHFFFAOYSA-N
SCHEMBL879185
XAA28262
A919782
22282-62-8
DTXSID50471362
2-iodo-5-methyl-pyridine
MFCD11656389
2-Iodo-5-methylpyridine
FT-0719974
N12262
Pyridine, 2-iodo-5-methyl-
CS-12036
SY036106
AKOS023095387
Pyridine,2-iodo-5-methyl
QC-3749

MDL Number

MFCD11656389

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 2-Iodo-5-methylpyridine (CAS: 22282-62-8)?

2-Iodo-5-methylpyridine (CAS: 22282-62-8) is a crystalline solid with a molecular weight of approximately 229.02 g/mol. It has moderate solubility in common organic solvents like ethanol and acetone. The compound shows limited reactivity but can undergo substitution reactions with good yield. It is stable under normal temperature and pressure conditions.

How is 2-Iodo-5-methylpyridine (CAS: 22282-62-8) typically synthesized?

2-Iodo-5-methylpyridine is typically synthesized through a reaction between 5-methylpyridine and iodine in the presence of a catalyst such as iron trifluoromethanesulfonate. The method yields a high percentage of the desired product with good selectivity. The reaction is carried out at room temperature and atmospheric pressure.

What industries use 2-Iodo-5-methylpyridine (CAS: 22282-62-8)?

2-Iodo-5-methylpyridine (CAS: 22282-62-8) finds applications in pharmaceuticals, particularly as a potential intermediate in the synthesis of certain drugs. It is also used in the development of sensors and in the synthesis of materials for semiconductor applications.

What precautions should be taken when handling 2-Iodo-5-methylpyridine (CAS: 22282-62-8)?

When handling 2-Iodo-5-methylpyridine (CAS: 22282-62-8), it is important to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately with appropriate absorbent materials, and the area should be thoroughly ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.