6-chloro-2-methyl-3-nitropyridine

Basic Information

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CAS Number

22280-60-0

Molecular Formula

C6H5ClN2O2

Molecular Weight

172.57 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

Solid

Melting Point

53.0 to 57.0 deg-C

Boiling Point

255.9℃ at 760 mmHg

Flash Point

108.5℃

Refractive Index

1.5500 (estimate)

SMILES

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CC1=C(C=CC(=N1)Cl)[N+](=O)[O-]

InChI

InChI=1S/C6H5ClN2O2/c1-4-5(9(10)11)2-3-6(7)8-4/h2-3H,1H3

InChIKey

GHSRMSJVYMITDX-UHFFFAOYSA-N

LogP

2.47480

Complexity

159

Safety Information

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Hazard Statement

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

SY009114
J-508960
PB47353
6-Chloro-2-methyl-3-nitropyridine, AldrichCPR
NCIOpen2_000630
Z1255360809
NSC 75592
AC-907/25004504
Q-103403
BCP22214
6-Chloro-3-nitro-2-picoline
6-Chloro-2-methyl-3-nitropyridine #
NSC75592
2-Chloro-5-nitro-6-picoline
NSC-75592
6-Chloro-2-methyl-3-nitro-pyridine
22280-60-0
C2434
HY-32800
SCHEMBL381701
DTXSID50291446
FT-0600694
PS-4909
EN300-107675
2-CHLORO-6-METHYL-5-NITROPYRIDINE
6-chloro-3-nitro-2-methylpyridine
2-Chloro-5-nitro-6-picoline (2-Chloro-6-methyl-5-nitropyridine)
AM20050961
6-Chloro-2-methyl-3-nitropyridine
MFCD00234160
2-Chloro-6-Methyl-3-Nitro Pyridine

MDL Number

MFCD00234160

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 6-chloro-2-methyl-3-nitropyridine (CAS: 22280-60-0)?

6-Chloro-2-methyl-3-nitropyridine is a crystalline solid with a molecular weight of approximately 195.62 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. Chemically, it is highly reactive due to the presence of the nitro and chlorine substituents, which can participate in various electrophilic aromatic substitution reactions.

How is 6-chloro-2-methyl-3-nitropyridine (CAS: 22280-60-0) typically synthesized?

6-Chloro-2-methyl-3-nitropyridine can be synthesized via nitration of 2-methyl-3-chloropyridine using nitric acid in the presence of concentrated sulfuric acid as a catalyst. The reaction is carried out under controlled conditions to achieve high selectivity and yield. This method ensures the formation of the desired nitro derivative while minimizing side reactions.

What industries use 6-chloro-2-methyl-3-nitropyridine (CAS: 22280-60-0)?

6-Chloro-2-methyl-3-nitropyridine is used in the pharmaceutical industry for the synthesis of certain drugs due to its antibacterial and antifungal properties. It also finds applications in the polymer industry for the development of advanced materials. Additionally, it is utilized in the semiconductor industry for fabrication processes and in sensors for detecting specific chemical species.

What precautions should be taken when handling 6-chloro-2-methyl-3-nitropyridine (CAS: 22280-60-0)?

Handling 6-chloro-2-methyl-3-nitropyridine requires strict safety measures. Always wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to avoid inhalation. If a spill occurs, immediately clean it up using appropriate absorbent materials and dispose of them according to local regulations. Always refer to a Material Safety Data Sheet (MSDS) for detailed safety information.