4-(4-Acetamido-3-fluorophenoxy)-N-methyl-2-pyridinecarboxamide | CAS No. 2141961-84-2
4-(4-Acetamido-3-fluorophenoxy)-N-methyl-2-pyridinecarboxamide
Basic Information
CAS Number
2141961-84-2
Molecular Formula
C15H14FN3O3
Molecular Weight
303.29 g/mol
AD
Chemical Classification
Basic Physical Properties
Synonyms & References
English
- 4-(4-acetamido-3-fluorophenoxy)-N-methylpicolinamide
- YX0I2UK6ON
- 4-(4-Acetamido-3-fluorophenoxy)-N-methylpyridine-2-carboxamide
- Regorafenib monohydrate impurity B [EP]
- D77496
FAQ
What are the physical and chemical properties of 4-(4-Acetamido-3-fluorophenoxy)-N-methyl-2-pyridinecarboxamide (CAS: 2141961-84-2)?
4-(4-Acetamido-3-fluorophenoxy)-N-methyl-2-pyridinecarboxamide is a crystalline compound with a molecular weight of approximately 386.31 g/mol. It has a low solubility in water but is soluble in organic solvents like DMSO, DMF, and acetonitrile. Chemically, it is stable under normal conditions but is sensitive to strong acids and bases. It exhibits moderate reactivity in biological systems, making it suitable for medicinal chemistry applications.
How is 4-(4-Acetamido-3-fluorophenoxy)-N-methyl-2-pyridinecarboxamide (CAS: 2141961-84-2) typically synthesized?
4-(4-Acetamido-3-fluorophenoxy)-N-methyl-2-pyridinecarboxamide is synthesized via a multi-step process involving amide coupling and fluorination reactions. The synthesis typically requires catalysts such as HATU and a base like DIPEA. The overall yield is around 50-60%, with good selectivity for the desired product.
What industries use 4-(4-Acetamido-3-fluorophenoxy)-N-methyl-2-pyridinecarboxamide (CAS: 2141961-84-2)?
This compound is primarily used in the pharmaceutical industry, particularly in the development of anti-inflammatory and analgesic drugs. It may also find applications in sensor technology for detecting specific chemical species and in the synthesis of functional materials for electronic devices.
What precautions should be taken when handling 4-(4-Acetamido-3-fluorophenoxy)-N-methyl-2-pyridinecarboxamide (CAS: 2141961-84-2)?
When handling 4-(4-Acetamido-3-fluorophenoxy)-N-methyl-2-pyridinecarboxamide, appropriate personal protective equipment (PPE) should be worn, including gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize inhalation risks. Spills should be cleaned up with appropriate absorbents and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage instructions.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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