4-(4-Acetamido-3-fluorophenoxy)-N-methyl-2-pyridinecarboxamide(CAS: 2141961-84-2)

4-(4-Acetamido-3-fluorophenoxy)-N-methyl-2-pyridinecarboxamide is a crystalline compound with a molecular weight of approximately 386.31 g/mol. It has a low solubility in water but is soluble in organic solvents like DMSO, DMF, and acetonitrile. Chemically, it is stable under normal conditions but is sensitive to strong acids and bases. It exhibits moderate reactivity in biological systems, making it suitable for medicinal chemistry applications.

4-(4-Acetamido-3-fluorophenoxy)-N-methyl-2-pyridinecarboxamide is synthesized via a multi-step process involving amide coupling and fluorination reactions. The synthesis typically requires catalysts such as HATU and a base like DIPEA. The overall yield is around 50-60%, with good selectivity for the desired product.

This compound is primarily used in the pharmaceutical industry, particularly in the development of anti-inflammatory and analgesic drugs. It may also find applications in sensor technology for detecting specific chemical species and in the synthesis of functional materials for electronic devices.

When handling 4-(4-Acetamido-3-fluorophenoxy)-N-methyl-2-pyridinecarboxamide, appropriate personal protective equipment (PPE) should be worn, including gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize inhalation risks. Spills should be cleaned up with appropriate absorbents and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage instructions.