2'-O-Methyluridine

Basic Information

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CAS Number

2140-76-3

Molecular Formula

C10H14N2O6

Molecular Weight

258.23 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Physical State

White to Yellow Solid

Melting Point

159.0 to 163.0 deg-C

Density

1.53

Refractive Index

1.611

SMILES

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COC1C(C(OC1N2C=CC(=O)NC2=O)CO)O

InChI

InChI=1S/C10H14N2O6/c1-17-8-7(15)5(4-13)18-9(8)12-3-2-6(14)11-10(12)16/h2-3,5,7-9,13,15H,4H2,1H3,(H,11,14,16)/t5-,7-,8-,9-/m1/s1

InChIKey

SXUXMRMBWZCMEN-ZOQUXTDFSA-N

LogP

-2.197799999999999

Topological Polar Surface Area

113.78 Å²

Hydrogen Bond Donor/Acceptor

3 / 8

Complexity

385

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]pyrimidine-2,4-dione
2 inverted exclamation marka-O-Methyluridine
2'-o-Methyluridine, AldrichCPR
AKOS015850961
UNII-399VZB6TMB
AS-12177
1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
MFCD00056054
J-700070
1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
HY-W011824
AKOS015919383
BP-58662
2'-O-methyl-uridine
399VZB6TMB
2'-O-Methyluridine
SCHEMBL25866
Q15632791
PD158289
Uridine, 2'-O-methyl-
O(2')-Methyluridine
CHEBI:19227
2'-O-Methyl Uridine
2140-76-3
CS-W012540
EN300-19734319
4-Hydroxy-1-(2-O-methylpentofuranosyl)pyrimidin-2(1H)-one
O2'-Methyluridine
DTXSID10943959
-2'-O-METHYLURIDINE
2'-O-METHYLURIDINE (CHIRAL)

MDL Number

MFCD00056054

Customs Code

2934999090

FAQ

What is 2'-O-Methyluridine (CAS: 2140-76-3)?

2'-O-Methyluridine is a modified nucleoside with the chemical formula C10H14N2O5. It is structurally similar to uridine but features an additional methyl group on the 2' oxygen atom of the ribose ring. This compound is commonly used in molecular biology and pharmaceutical research due to its unique chemical properties and stability compared to natural nucleosides.

What are the main uses of 2'-O-Methyluridine (CAS: 2140-76-3)?

2'-O-Methyluridine is primarily used in the synthesis of RNA analogs, as a component in molecular biology research, and in pharmaceutical applications for drug development. It also finds use in the production of nucleic acid-based therapeutics and as a building block in the creation of modified oligonucleotides for gene targeting and antisense therapy.

Is 2'-O-Methyluridine (CAS: 2140-76-3) safe?

2'-O-Methyluridine is generally considered safe when handled properly in laboratory and industrial settings. However, as with any chemical, it should be treated with caution. Safety data sheets recommend protective measures such as gloves and goggles, and it is important to follow standard safety protocols to avoid potential exposure risks.

How should 2'-O-Methyluridine (CAS: 2140-76-3) be stored?

2'-O-Methyluridine should be stored in a cool, dry place away from direct light. It is typically kept in airtight containers at temperatures below 25°C and with humidity levels below 60% to maintain stability. Proper storage helps prevent degradation and ensures the compound remains effective for research and application purposes.