(4R)-4-Fluoro-L-proline

Basic Information

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CAS Number

21156-44-5

Molecular Formula

C5H8FNO2

Molecular Weight

133.12 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Electronic Chemicals Semiconductor Materials Etchants

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

SMILES

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C1C(CNC1C(=O)O)F

InChI

InChI=1S/C5H8FNO2/c6-3-1-4(5(8)9)7-2-3/h3-4,7H,1-2H2,(H,8,9)/t3-,4+/m1/s1

InChIKey

ZIWHMENIDGOELV-DMTCNVIQSA-N

LogP

-0.22900000000000004

Topological Polar Surface Area

49.33 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

128

Synonyms & References

English

Q27460382
AKOS006282505
CS-0037623
(2S,4R)-4-fluoropyrrolidine-2-carboxylic acid, AldrichCPR
ZIWHMENIDGOELV-DMTCNVIQSA-N
AC-33232
(2S,4R)-4-Fluoropyrrolidine-2-carboxylicacid
trans-4-Fluoropyrrolidine-2-carboxylic acid
AC-2246
F0818
AC-14453
trans-4-Fluoro-l-proline
DTXSID801313977
A817629
CHEMBL1232810
AKOS005063376
rel-((2S,4R)-4-Fluoropyrrolidine-2-carboxylic acid),labeled with tritium
AMY13640
2507-61-1
SCHEMBL305909
C5H8FNO2
21156-44-5
(2S, 4R)-4-Fluoroproline
EN300-89701
MFCD02683982
(2S,4R)-4-FLUORO-PYRROLIDINE-2-CARBOXYLIC ACID
H-Pro(4-F)-OH
HY-W044620
PD197169
(2S,4R)-4-Fluoro-pyrrolidine-2-carboxylic acid;(2S,4R)-4-Fluoropyrrolidine-2-carboxylic acid
L-PROLINE, 4-FLUORO-, (4R)-

MDL Number

MFCD07366527

FAQ

What is (4R)-4-Fluoro-L-proline (CAS: 21156-44-5)?

(4R)-4-Fluoro-L-proline is a chiral amino acid derivative with a 4-fluoro substituent at the α-carbon. It is an important intermediate in the synthesis of pharmaceuticals and other biologically active compounds. It has the chemical formula C5H7FO2N and is a white or off-white crystalline powder with a melting point of about 229°C.

What are the main uses of (4R)-4-Fluoro-L-proline (CAS: 21156-44-5)?

(4R)-4-Fluoro-L-proline is primarily used as a building block in the synthesis of pharmaceuticals, particularly those targeting G-protein coupled receptors (GPCRs). It is also utilized in the development of bioactive compounds and as a research tool in drug discovery and molecular biology.

Is (4R)-4-Fluoro-L-proline (CAS: 21156-44-5) safe?

(4R)-4-Fluoro-L-proline is generally considered safe when handled with appropriate precautions. However, it should be used in a well-ventilated area to avoid inhalation of dust and to prevent skin contact. Protective equipment such as gloves and goggles should be worn to ensure safety.

How should (4R)-4-Fluoro-L-proline (CAS: 21156-44-5) be stored?

(4R)-4-Fluoro-L-proline should be stored in a cool, dry place away from direct sunlight and heat sources. It should be kept in a tightly sealed container to minimize exposure to air and moisture. The temperature should be maintained below 25°C to ensure stability and minimize degradation.