2-(4-Bromophenyl)pyrimidine

Basic Information

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CAS Number

210354-17-9

Molecular Formula

C10H7BrN2

Molecular Weight

235.08 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

136.0 to 140.0 deg-C

Boiling Point

237.6±32.0 ºC (760 Torr),

Flash Point

97.5±25.1 ºC,

SMILES

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C1=CN=C(N=C1)C2=CC=C(C=C2)Br

InChI

InChI=1S/C10H7BrN2/c11-9-4-2-8(3-5-9)10-12-6-1-7-13-10/h1-7H

InChIKey

PFLPZHPQFNFTRF-UHFFFAOYSA-N

LogP

2.9061000000000012

Topological Polar Surface Area

25.78 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

149

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

4-(Pyrimidin-2-yl)bromobenzene
2-(4-Bromophenyl)pyrimidine
2-(4-bromo-phenyl)pyrimidine
PFLPZHPQFNFTRF-UHFFFAOYSA-N
Pyrimidine, 2-(4-bromophenyl)-
OR6403
SBB054159
7144AD
FCH1386182
SB59333
SCHEMBL1000179
B5806
2-(4-Bromo-phenyl)-pyrimidine
EN300-745718
T70556
TS-03312
MFCD08056329
210354-17-9
AKOS022533423
DB-312633

MDL Number

MFCD08056329

FAQ

What are the physical and chemical properties of 2-(4-Bromophenyl)pyrimidine (CAS: 210354-17-9)?

2-(4-Bromophenyl)pyrimidine is a crystalline solid with a molecular weight of approximately 255.02 g/mol. It has a low solubility in water but is more soluble in organic solvents such as dichloromethane and ethyl acetate. This compound is not highly reactive under normal conditions but can undergo substitution reactions. It is used in the synthesis of pharmaceuticals and other organic compounds.

How is 2-(4-Bromophenyl)pyrimidine (CAS: 210354-17-9) typically synthesized?

2-(4-Bromophenyl)pyrimidine is typically synthesized by the reaction of 4-bromophenylhydrazine with 2-chloropyrimidine. This process involves a classical condensation reaction under basic conditions. The yield can vary, but the method is straightforward and widely used in academic and industrial settings.

What industries use 2-(4-Bromophenyl)pyrimidine (CAS: 210354-17-9)?

2-(4-Bromophenyl)pyrimidine is primarily used in the pharmaceutical industry for the synthesis of active pharmaceutical ingredients. It also finds applications in the polymer industry for the development of new materials with specific properties. Additionally, it is utilized in the production of sensors and semiconductors due to its unique chemical and physical properties.

What precautions should be taken when handling 2-(4-Bromophenyl)pyrimidine (CAS: 210354-17-9)?

When handling 2-(4-Bromophenyl)pyrimidine, it is important to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate chemicals. Refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.