CETUXIMAB | CAS No. 205923-56-4

CETUXIMAB

Basic Information

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CAS Number

205923-56-4

Molecular Weight

354.29 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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Br.OC(CCCCCN1C(=C)C(C)(C)C2=CC=CC=C12)=O

InChI

InChI=1S/C17H23NO2.BrH/c1-13-17(2,3)14-9-6-7-10-15(14)18(13)12-8-4-5-11-16(19)20;/h6-7,9-10H,1,4-5,8,11-12H2,2-3H3,(H,19,20);1H

InChIKey

SVMKEDBUSSWSFY-UHFFFAOYSA-N

LogP

4.520800000000004

Topological Polar Surface Area

40.54 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Synonyms & References

English

CETUXIMAB
Erbitux
Hsdb 7454
Immunoglobulin G1, anti-(human epidermal growth factor receptor) (human-mouse monoclonal C225 gamma1-chain), disulfide with human-mouse monoclonal C225 kappa-chain, dimer
Unii-pqx0D8J21j
EGFR antibody
IMC 225
CetuxiMab(C225)
ImmunoglobulinG1, anti-(human epidermal growth factor receptor) (human-mouse monoclonal C225 g...
C225
IMC-C 225
C 225
Cetuximab

FAQ

What are the physical and chemical properties of CETUXIMAB (CAS: 205923-56-4)?

Cetuximab is a monoclonal antibody with a molecular weight of approximately 145 kDa. It is a protein that is typically produced in a crystalline form. Cetuximab has a low solubility in water and is relatively stable. It does not react with common inorganic acids or bases but may be susceptible to degradation under harsh conditions. Its stability and solubility make it suitable for pharmaceutical applications.

How is CETUXIMAB (CAS: 205923-56-4) typically synthesized?

Cetuximab is synthesized through a complex process involving hybridoma technology. The antibody is produced in mammalian cells, such as Chinese hamster ovary (CHO) cells. The production process includes cell culture, antibody purification, and formulation. The yield is relatively high, and the method ensures high selectivity and purity.

What industries use CETUXIMAB (CAS: 205923-56-4)?

Cetuximab is primarily used in the pharmaceutical industry, particularly in oncology. It is used as a targeted therapy for treating certain types of cancer, such as colorectal cancer and squamous cell carcinoma. Additionally, research into its applications in other areas, such as biosensors and drug delivery systems, is ongoing.

What precautions should be taken when handling CETUXIMAB (CAS: 205923-56-4)?

Proper handling of cetuximab requires the use of personal protective equipment (PPE) such as gloves and lab coats. It should be handled in a well-ventilated area, preferably in a fume hood. In case of a spill, it should be cleaned up carefully using appropriate absorbent materials. For more detailed safety information, refer to the safety data sheet (SDS) for cetuximab.