Amifostine | CAS No. 20537-88-6

Amifostine

Basic Information

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CAS Number

20537-88-6

Molecular Formula

C5H15N2O3PS

Molecular Weight

214.23 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Agricultural Chemicals Pesticides Insecticides

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Melting Point

160-166°C

SMILES

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C(CN)CNCCSP(=O)(O)O

InChI

InChI=1S/C5H15N2O3PS/c6-2-1-3-7-4-5-12-11(8,9)10/h7H,1-6H2,(H2,8,9,10)

InChIKey

JKOQGQFVAUAYPM-UHFFFAOYSA-N

LogP

-0.2492999999999997

Topological Polar Surface Area

95.58 Å²

Hydrogen Bond Donor/Acceptor

5 / 5

Complexity

152

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

AMIFOSTINE [MI]
S 8744
CCG-35734
KBio2_000812
S-2-(3-aminopropylamino)ethyl O,O-dihydrogen phosphorothioate
NCGC00015073-02
BRN 2088122
NCGC00015073-01
AMIFOSTINE [HSDB]
2-(3-aminopropylamino)ethylsulfanylphosphonic acid;Amifostine
FT-0622272
Amifostine Ethiofos
AB00053311-05
MFCD00233058
KBio2_005948
SR-01000075680-3
CAS-20537-88-6
({2-[(3-aminopropyl)amino]ethyl}sulfanyl)phosphonic acid
MLS000028473
Acide ((amino-3 propylamino)-2 ethyl)-S-phosphorothioique
DTXCID602585
Amifostine [USAN:INN:BAN]
SBI-0050018.P003
WR 2721C
S-{2-[(3-aminopropyl)amino]ethyl} dihydrogen thiophosphate
Ethanethiol, dihydrogen phosphate (ester)
NCGC00015073-15
AS-13020
NS00005651
ILA426L95O
20537-88-6

MDL Number

MFCD00233058

Customs Code

2930909090

FAQ

What is Amifostine (CAS: 20537-88-6)?

Amifostine is a pharmacological radioprotectant, used to protect normal tissues from radiation damage. It has a chemical formula of C12H21NO7S and is a white, crystalline powder. It is also known as Ethyol, an organosulfur compound.

What are the main uses of Amifostine (CAS: 20537-88-6)?

Amifostine is primarily used as a radioprotectant in cancer chemotherapy to protect normal tissues from radiation damage. It is also used in the treatment of radiation-induced cystitis and nephritis. Additionally, it is used in the prevention of iatrogenic kidney damage during cisplatin therapy.

Is Amifostine (CAS: 20537-88-6) safe?

Amifostine is generally considered safe when used as directed. However, it can cause side effects such as nausea, vomiting, and hypotension. It should be handled with care, and healthcare providers should follow safety guidelines and use appropriate personal protective equipment. Toxicity is low, and it is subject to regulatory safety standards.

How should Amifostine (CAS: 20537-88-6) be stored?

Amifostine should be stored at 2-8°C (36-46°F) in the dark to maintain its stability. It should be protected from light, kept in a tightly closed container, and stored in a well-ventilated area away from heat and sources of ignition. It should be handled with care to avoid exposure to skin or eyes, and proper disposal methods should be followed.