Amiloride Hydrochloride Dihydrate | CAS No. 2016-88-8

Q: What are the physical and chemical properties of Amiloride Hydrochloride Dihydrate (CAS: 2016-88-8)?

Amiloride Hydrochloride Dihydrate is a white, crystalline powder with a molecular weight of approximately 348.74 g/mol. It is highly soluble in water and alcohol but less soluble in nonpolar solvents. Chemically, it is slightly basic and can react with strong acids. This compound is commonly used in pharmaceutical applications and has a dihydrate form, indicating it contains two water molecules per molecule.

Q: How is Amiloride Hydrochloride Dihydrate (CAS: 2016-88-8) typically synthesized?

Amiloride Hydrochloride Dihydrate is synthesized through a multi-step process involving the condensation of 1,2-phenylene diamine and chloroacetic acid, followed by hydrolysis and crystallization. Commonly, this synthesis involves the use of a catalyst and nitrogen pressure to enhance yield and selectivity. The process typically yields over 95% purity.

Q: What industries use Amiloride Hydrochloride Dihydrate (CAS: 2016-88-8)?

Amiloride Hydrochloride Dihydrate is primarily used in the pharmaceutical industry for its diuretic and antihypertensive properties. It is also utilized in the food industry as a flavor enhancer and preservative. Additionally, it has applications in the polymer industry for its ability to improve the mechanical properties of polymer materials.

Q: What precautions should be taken when handling Amiloride Hydrochloride Dihydrate (CAS: 2016-88-8)?

When handling Amiloride Hydrochloride Dihydrate, it is important to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Ensure that the compound is stored away from heat and direct sunlight. In case of a spill, it should be cleaned up immediately using appropriate containment and disposal methods as outlined in the safety data sheet (SDS). Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation of dust or fumes.

Amiloride Hydrochloride Dihydrate

Basic Information

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CAS Number

2016-88-8

Molecular Formula

C6H13Cl2N7O3

Molecular Weight

266.09 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

293-294 ºC

Boiling Point

628.1°C at 760 mmHg

Water Solubility

<0.1 g/100 mL at 19.5 ºC

Solubility

H2O: 50 mg/mL, clear, yellow-green

SMILES

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Cl.NC(=N)NC(=O)c1nc(Cl)c(N)nc1N

InChI

InChI=1S/C6H8ClN7O.ClH/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;/h(H4,8,9,13)(H4,10,11,14,15);1H

InChIKey

ACHKKGDWZVCSNH-UHFFFAOYSA-N

LogP

-0.6605300000000001

Topological Polar Surface Area

156.79 Å²

Hydrogen Bond Donor/Acceptor

8 / 8

Complexity

279

Safety Information

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Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

H311 Toxic in contact with skin
Acute toxicity, dermal

H331 Toxic if inhaled
Acute toxicity, inhalation

Hazard Class

Class 6.1 Class 6.1

Synonyms & References

English

amiloride hydrochloride hydrate
Amiloride Hydrochloride
Amiloride HCl
Amiloride (hydrochloride)
Amiloride HCl dihydrate
AMILORIDE HYDROCHLORIDE, USP
MK-870 hydrochloride
3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide hydrochloride
3,5-Diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide Hydrochloride Hydrate
AMILORIDE
amiloridechloride
Amiloridhydrochlorid
AMIPRAMIDIN
AMipraMidine
AMipraMizi
AMIPRAMIZIDE
amiprazidine
Arumil
GUANAMPRAZINE
HCL AMILORIDE HCL
N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride hydrate
N-Amido-3,5-diamino-6-chloropyrazine carboxamidehydrochloride
N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride
Amiloride chloride
Amiloride hydrochloride anhydrous
Amiloride, Hydrochloride
MLS000028442
Midamor
SMR000058414
N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide monohydrochloride
DSSTox_CID_4452

MDL Number

MFCD00058197

Customs Code

29339980

FAQ

What are the physical and chemical properties of Amiloride Hydrochloride Dihydrate (CAS: 2016-88-8)?

Amiloride Hydrochloride Dihydrate is a white, crystalline powder with a molecular weight of approximately 348.74 g/mol. It is highly soluble in water and alcohol but less soluble in nonpolar solvents. Chemically, it is slightly basic and can react with strong acids. This compound is commonly used in pharmaceutical applications and has a dihydrate form, indicating it contains two water molecules per molecule.

How is Amiloride Hydrochloride Dihydrate (CAS: 2016-88-8) typically synthesized?

Amiloride Hydrochloride Dihydrate is synthesized through a multi-step process involving the condensation of 1,2-phenylene diamine and chloroacetic acid, followed by hydrolysis and crystallization. Commonly, this synthesis involves the use of a catalyst and nitrogen pressure to enhance yield and selectivity. The process typically yields over 95% purity.

What industries use Amiloride Hydrochloride Dihydrate (CAS: 2016-88-8)?

Amiloride Hydrochloride Dihydrate is primarily used in the pharmaceutical industry for its diuretic and antihypertensive properties. It is also utilized in the food industry as a flavor enhancer and preservative. Additionally, it has applications in the polymer industry for its ability to improve the mechanical properties of polymer materials.

What precautions should be taken when handling Amiloride Hydrochloride Dihydrate (CAS: 2016-88-8)?

When handling Amiloride Hydrochloride Dihydrate, it is important to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Ensure that the compound is stored away from heat and direct sunlight. In case of a spill, it should be cleaned up immediately using appropriate containment and disposal methods as outlined in the safety data sheet (SDS). Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation of dust or fumes.