Amiloride Hydrochloride Dihydrate(CAS: 2016-88-8)

Amiloride Hydrochloride Dihydrate is a white, crystalline powder with a molecular weight of approximately 348.74 g/mol. It is highly soluble in water and alcohol but less soluble in nonpolar solvents. Chemically, it is slightly basic and can react with strong acids. This compound is commonly used in pharmaceutical applications and has a dihydrate form, indicating it contains two water molecules per molecule.

Amiloride Hydrochloride Dihydrate is synthesized through a multi-step process involving the condensation of 1,2-phenylene diamine and chloroacetic acid, followed by hydrolysis and crystallization. Commonly, this synthesis involves the use of a catalyst and nitrogen pressure to enhance yield and selectivity. The process typically yields over 95% purity.

Amiloride Hydrochloride Dihydrate is primarily used in the pharmaceutical industry for its diuretic and antihypertensive properties. It is also utilized in the food industry as a flavor enhancer and preservative. Additionally, it has applications in the polymer industry for its ability to improve the mechanical properties of polymer materials.

When handling Amiloride Hydrochloride Dihydrate, it is important to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Ensure that the compound is stored away from heat and direct sunlight. In case of a spill, it should be cleaned up immediately using appropriate containment and disposal methods as outlined in the safety data sheet (SDS). Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation of dust or fumes.