6-CHLOROPURINE RIBOSIDE

Basic Information

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CAS Number

2004-06-0

Molecular Formula

C10H11ClN4O4

Molecular Weight

286.68 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

161-163 ºC

Boiling Point

614.8°C at 760 mmHg

Flash Point

325.6ºC

Refractive Index

-45 ° (C=0.8, H2O)

Specific Rotation

-42--48° (c=0.8, H2O)

SMILES

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C1=NC2=C(C(=N1)Cl)N=CN2C3C(C(C(O3)CO)O)O

InChI

InChI=1S/C10H11ClN4O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2/t4-,6-,7-,10?/m1/s1

InChIKey

XHRJGHCQQPETRH-VTHZCTBJSA-N

LogP

-0.9088000000000003

Topological Polar Surface Area

113.52000000000001 Å²

Hydrogen Bond Donor/Acceptor

3 / 8

Complexity

339

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

5399-87-1
HG1394
Z1741975385
(2R,3R,4S,5R)-2-(6-Chloro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
AM83942
NSC 4910
9H-Purine, 6-chloro-9-beta-D-ribofuranosyl-
6-Chloro-9-(beta-D-ribofuranosyl)-purine
(2R,3R,4S,5R)-2-(6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)-tetrahydrofuran-3,4-diol;(2R,3R,4S,5R)-2-(6-Chloro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
DTXSID001313678
(2R,3R,4S,5R)-2-(6-chloropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
6-chloro-9(beta-D-ribofuranosyl)-purine
AKOS015995297
CHEMBL397974
A852095
EINECS 217-904-8
PD164076
6-chlorpurine riboside
4-26-00-01745 (Beilstein Handbook Reference)
6-Chloropurine-9-
(2R,3R,4S,5R)-2-(6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)-tetrahydrofuran-3,4-diol
6-Chloro-9-ss -D-ribofuranosyl-9H-purine
A814198
6-Chloro-9-(beta-D-ribofuranosyl)purine
6-Chloropurine ribonucleoside
6-Chloro-9-(b-D-ribofuranosyl)purine
6-Chloropurine-9-b-D-ribofuranoside
6-Chloronebularine
XHRJGHCQQPETRH-KQYNXXCUSA-N
AKOS015896897
6-chloro-9-beta-D-ribofuranosylpurine

MDL Number

MFCD00005738

Customs Code

29389090

FAQ

What are the physical and chemical properties of 6-CHLOROPURINE RIBOSIDE (CAS: 2004-06-0)?

6-Chloropurine riboside (CAS: 2004-06-0) is a white crystalline solid with a molecular weight of approximately 286.04 g/mol. It has a high solubility in water and is less soluble in organic solvents. This compound is relatively stable but can hydrolyze in basic media. It is used in the synthesis of nucleoside analogs and in pharmaceutical research.

How is 6-CHLOROPURINE RIBOSIDE (CAS: 2004-06-0) typically synthesized?

6-Chloropurine riboside is typically synthesized by the condensation of 6-chloropurine with ribose in the presence of a base such as sodium hydride. The reaction involves the formation of an ester linkage between the purine base and the ribose sugar. The yield is generally high, and the method is suitable for preparative scale synthesis.

What industries use 6-CHLOROPURINE RIBOSIDE (CAS: 2004-06-0)?

6-Chloropurine riboside (CAS: 2004-06-0) is primarily used in the pharmaceutical industry for the development of antiviral drugs. It is also utilized in academic research for the study of nucleosides and their biological activities. Additionally, it has potential applications in the synthesis of other nucleoside analogs for therapeutic purposes.

What precautions should be taken when handling 6-CHLOROPURINE RIBOSIDE (CAS: 2004-06-0)?

When handling 6-chloropurine riboside (CAS: 2004-06-0), it is important to wear appropriate personal protective equipment (PPE) such as gloves and lab coat. Ensure the work is done in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency response guidelines.