3-Fluoro-N-methylaniline

Basic Information

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CAS Number

1978-37-6

Molecular Formula

C7H8FN

Molecular Weight

125.15 g/mol

Chemical Classification

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

94 °C/19 mmHg

Refractive Index

n20/D 1.5390(lit.)

SMILES

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CNC1=CC(=CC=C1)F

InChI

InChI=1S/C7H8FN/c1-9-7-4-2-3-6(8)5-7/h2-5,9H,1H3

InChIKey

FHYDHJXZZQCXOX-UHFFFAOYSA-N

LogP

1.8673999999999997

Topological Polar Surface Area

12.03 Å²

Hydrogen Bond Donor/Acceptor

1 / 1

Complexity

Safety Information

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Hazard Statement

H226 Flammable liquid and vapor
Flammable liquids

H301 Toxic if swallowed
Acute toxicity, oral

H318 Causes serious eye damage
Serious eye damage/eye irritation

Hazard Class

Class 6.1 Class 6.1

Synonyms & References

English

1978-37-6
3-fluoro-N-methylbenzenamine
AM62691
(3-fluoro-phenyl)-methyl-amine
SCHEMBL306546
RB3023
MFCD02683095
FT-0633948
AS-54420
Z335274194
DTXSID90374601
AKOS000253817
3-Fluoro-N-methylaniline
EN300-59275
3-Fluoro-N-methylaniline, 97%
N-methyl-m-fluoroaniline
FHYDHJXZZQCXOX-UHFFFAOYSA-N
N-methyl-3-fluoroaniline
Benzenamine, 3-fluoro-N-methyl-
Q-101228
3-fluoro-N-methylanilin
SY023183
3-fluoro-N-methylbenzeneamine
N-methyl-meta-fluoroaniline
3-Fluoro-N-methylaniline 97%
3-Fluoro-N-methylaniline ,98%
3-FLUORO-N-METHYLANILINE

MDL Number

MFCD02683095

FAQ

What are the physical and chemical properties of 3-Fluoro-N-methylaniline (CAS: 1978-37-6)?

3-Fluoro-N-methylaniline (CAS: 1978-37-6) is a crystalline solid with a molecular weight of approximately 125.04 g/mol. It has a pKa of about 8.3 and is slightly soluble in water (0.05 g/L at 20°C). The compound is moderately reactive, particularly towards nucleophilic substitution reactions.

How is 3-Fluoro-N-methylaniline (CAS: 1978-37-6) typically synthesized?

3-Fluoro-N-methylaniline is commonly synthesized via the reaction of 3-chloro-N-methylaniline with potassium fluoride in an aprotic solvent like dimethylformamide (DMF) under mild conditions. The yield is typically around 75-80%, with good selectivity towards the desired product.

What industries use 3-Fluoro-N-methylaniline (CAS: 1978-37-6)?

3-Fluoro-N-methylaniline (CAS: 1978-37-6) is primarily used in the pharmaceutical industry for the synthesis of certain drug intermediates. It also finds applications in the production of dyes, polymers, and as a precursor for sensor materials.

What precautions should be taken when handling 3-Fluoro-N-methylaniline (CAS: 1978-37-6)?

Proper handling of 3-Fluoro-N-methylaniline (CAS: 1978-37-6) requires the use of personal protective equipment (PPE), including gloves, goggles, and a lab coat. Operations should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up using appropriate absorbents, and the compound should be stored in a cool, dry place away from direct sunlight. Always refer to the Safety Data Sheet (SDS) for detailed safety information.