3-Fluoro-N-methylaniline(CAS: 1978-37-6)

3-Fluoro-N-methylaniline (CAS: 1978-37-6) is a crystalline solid with a molecular weight of approximately 125.04 g/mol. It has a pKa of about 8.3 and is slightly soluble in water (0.05 g/L at 20°C). The compound is moderately reactive, particularly towards nucleophilic substitution reactions.

3-Fluoro-N-methylaniline is commonly synthesized via the reaction of 3-chloro-N-methylaniline with potassium fluoride in an aprotic solvent like dimethylformamide (DMF) under mild conditions. The yield is typically around 75-80%, with good selectivity towards the desired product.

3-Fluoro-N-methylaniline (CAS: 1978-37-6) is primarily used in the pharmaceutical industry for the synthesis of certain drug intermediates. It also finds applications in the production of dyes, polymers, and as a precursor for sensor materials.

Proper handling of 3-Fluoro-N-methylaniline (CAS: 1978-37-6) requires the use of personal protective equipment (PPE), including gloves, goggles, and a lab coat. Operations should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up using appropriate absorbents, and the compound should be stored in a cool, dry place away from direct sunlight. Always refer to the Safety Data Sheet (SDS) for detailed safety information.