2,4-Dichloro-5-methoxypyrimidine

Basic Information

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CAS Number

19646-07-2

Molecular Formula

C5H4Cl2N2O

Molecular Weight

179.01 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

White to Yellow Solid

Melting Point

66.0 to 72.0 deg-C

Boiling Point

259.9°C at 760 mmHg

Water Solubility

Slightly soluble in water.

Flash Point

111℃

SMILES

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COC1=CN=C(N=C1Cl)Cl

InChI

InChI=1S/C5H4Cl2N2O/c1-10-3-2-8-5(7)9-4(3)6/h2H,1H3

InChIKey

ZTHHRSBDBPCCMZ-UHFFFAOYSA-N

LogP

1.7919999999999998

Topological Polar Surface Area

35.010000000000005 Å²

Hydrogen Bond Donor/Acceptor

0 / 3

Complexity

114

Safety Information

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GHS Hazard Pictograms

H302

H315

H318

H335

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H318 Causes serious eye damage
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Class CORROSIVE Class CORROSIVE

Synonyms & References

English

AB12653
AM20090132
2,6-dichloro-5-methoxy pyrimidine
5-METHOXY-2,4-DICHLOROPYRIMIDINE
PS-5359
5-METHOXY-2,4-DICHLORO PYRIMIDINE
AC-5931
D3508
MFCD02685670
AO-324/25087002
2,4-dichloro-5-methoxy-pyrimidine;2,4-Dichloro-5-methoxy pyrimidine
SY003225
2,4-Dichloro-5-methoxypyrimidine
SCHEMBL145005
2,4-Dichloro-5-methoxy-pyrimidin
2 pound not4-Dichloro-5-methoxy-pyrimidine
2,4-Dichloro-5-methoxypyrimidine, 97%
2,4-dichloropyrimidin-5-yl methyl ether
FT-0610014
2,4-Dichloro-5-methoxy-pyrimidine
AKOS005256731
2,4 dichloro-5-methoxypyrimidine
Pyrimidine, 2,4-dichloro-5-methoxy-
W-206446
CS-W002974
A813849
DTXSID00345044
EN300-85912
AC-2385
BCP22345
19646-07-2

MDL Number

MFCD02685670

Customs Code

2933599090

FAQ

What are the physical and chemical properties of 2,4-Dichloro-5-methoxypyrimidine (CAS: 19646-07-2)?

2,4-Dichloro-5-methoxypyrimidine is a solid, crystalline compound with a molecular weight of approximately 190.03 g/mol. It is slightly soluble in water but soluble in common organic solvents like ethanol and acetone. This compound exhibits moderate reactivity, particularly with nucleophiles, and is known for its stability in neutral to slightly acidic conditions.

How is 2,4-Dichloro-5-methoxypyrimidine (CAS: 19646-07-2) typically synthesized?

2,4-Dichloro-5-methoxypyrimidine is usually synthesized via the chlorination of 5-methoxypyrimidine followed by dehydration. The synthesis typically involves the use of thionyl chloride as a dehydrating agent. The reaction is carried out under mild conditions, and the yield is generally high (up to 90%). The reaction is selective and proceeds with good stereoselectivity.

What industries use 2,4-Dichloro-5-methoxypyrimidine (CAS: 19646-07-2)?

2,4-Dichloro-5-methoxypyrimidine is primarily used in the pharmaceutical industry as an intermediate for the synthesis of certain drugs. It is also utilized in the chemical industry for the production of herbicides and in the polymer industry as a stabilizer. Additionally, it has applications in the electronics industry for the fabrication of semiconductor materials.

What precautions should be taken when handling 2,4-Dichloro-5-methoxypyrimidine (CAS: 19646-07-2)?

When handling 2,4-Dichloro-5-methoxypyrimidine, it is essential to use appropriate personal protective equipment (PPE), including gloves and safety goggles. It should be handled in a well-ventilated area or a fume hood to prevent inhalation of vapors. In case of a spill, it should be cleaned up immediately using appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for specific safety guidelines and emergency procedures.