2,4-Dichloro-5-methoxypyrimidine(CAS: 19646-07-2)

2,4-Dichloro-5-methoxypyrimidine is a solid, crystalline compound with a molecular weight of approximately 190.03 g/mol. It is slightly soluble in water but soluble in common organic solvents like ethanol and acetone. This compound exhibits moderate reactivity, particularly with nucleophiles, and is known for its stability in neutral to slightly acidic conditions.

2,4-Dichloro-5-methoxypyrimidine is usually synthesized via the chlorination of 5-methoxypyrimidine followed by dehydration. The synthesis typically involves the use of thionyl chloride as a dehydrating agent. The reaction is carried out under mild conditions, and the yield is generally high (up to 90%). The reaction is selective and proceeds with good stereoselectivity.

2,4-Dichloro-5-methoxypyrimidine is primarily used in the pharmaceutical industry as an intermediate for the synthesis of certain drugs. It is also utilized in the chemical industry for the production of herbicides and in the polymer industry as a stabilizer. Additionally, it has applications in the electronics industry for the fabrication of semiconductor materials.

When handling 2,4-Dichloro-5-methoxypyrimidine, it is essential to use appropriate personal protective equipment (PPE), including gloves and safety goggles. It should be handled in a well-ventilated area or a fume hood to prevent inhalation of vapors. In case of a spill, it should be cleaned up immediately using appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for specific safety guidelines and emergency procedures.