Compound Q&A

How is 2,4-Dichloro-5-methoxypyrimidine (CAS: 19646-07-2) typically synthesized?

Answer

2,4-Dichloro-5-methoxypyrimidine
2,4-Dichloro-5-methoxypyrimidine is usually synthesized via the chlorination of 5-methoxypyrimidine followed by dehydration. The synthesis typically involves the use of thionyl chloride as a dehydrating agent. The reaction is carried out under mild conditions, and the yield is generally high (up to 90%). The reaction is selective and proceeds with good stereoselectivity.

About

CAS No 19646-07-2
English Name 2,4-Dichloro-5-methoxypyrimidine
Molecular Formula C5H4Cl2N2O
Molecular Weight 179.01 g/mol
SMILES COC1=CN=C(N=C1Cl)Cl
InChIKey ZTHHRSBDBPCCMZ-UHFFFAOYSA-N
Last Updated: 2025-09-25 13:48

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