(3R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-piperidinecarboxylic acid

Basic Information

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CAS Number

193693-67-3

Molecular Formula

C21H21NO4

Molecular Weight

351.4 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Physical State

White to Yellow Solid

Boiling Point

561.6 oCat760 mmHg

Density

1.293

Flash Point

293.5 oC

Refractive Index

1.62

SMILES

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C1CC(CN(C1)C(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24)C(=O)O

InChI

InChI=1S/C21H21NO4/c23-20(24)14-6-5-11-22(12-14)21(25)26-13-19-17-9-3-1-7-15(17)16-8-2-4-10-18(16)19/h1-4,7-10,14,19H,5-6,11-13H2,(H,23,24)/t14-/m1/s1

InChIKey

FINXGQXNIBNREL-CQSZACIVSA-N

LogP

3.7321000000000035

Topological Polar Surface Area

66.84 Å²

Hydrogen Bond Donor/Acceptor

1 / 5

Complexity

514

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

EN300-624080
1-n-fmoc-piperidine-3(r)-carboxylic acid
(3R)-1-(9H-fluoren-9-ylmethoxycarbonyl)piperidine-3-carboxylic acid
(R)-Fmoc-Nip-OH, >=99.0% (HPLC)
AKOS015897902
AS-37497
D-1-Fmoc-Nipecotic acid
AKOS015837414
FINXGQXNIBNREL-CQSZACIVSA-N
(r)-n-(9-fluorenylmethyloxycarbonyl)-nipecotic acid
(R)-Fmoc-nipecotic acid
MFCD04112683
193693-67-3
fmoc-(r)-nip-oh
CS-W011865
r-1-fmoc-piperidine-3-carboxylic acid
FMOC-D-PIC(3)-OH
(r)-fmoc-piperidine-3-carboxylic acid
fmoc-(r)-nipecotic acid
Z1033300680
(R)-Fmoc-Nip-OH
A13279
Q-103167
SCHEMBL4362743
(r)-piperidine-1,3-dicarboxylic acid 1-(9h-fluoren-9-ylmethyl) ester
(R)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)piperidine-3-carboxylic acid
Q-102969
(r)-fmoc-nip
(r)-1-fmoc-piperidine-3-carboxylic acid
(3R)-1-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]PIPERIDINE-3-CARBOXYLIC ACID
DTXSID40589228

MDL Number

MFCD04112683

Customs Code

2933399090

FAQ

What are the physical and chemical properties of (3R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-piperidinecarboxylic acid (CAS: 193693-67-3)?

(3R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-piperidinecarboxylic acid is a white crystalline solid with a molecular weight of approximately 425.43 g/mol. It is slightly soluble in water but has better solubility in organic solvents like methanol and acetonitrile. This compound exhibits good reactivity in amide formation and esterification reactions due to the presence of the carboxylic acid and fluorenylmethoxy carbonyl groups.

How is (3R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-piperidinecarboxylic acid (CAS: 193693-67-3) typically synthesized?

(3R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-piperidinecarboxylic acid can be synthesized via the coupling of fluorenylmethoxycarbonyl piperidine with the corresponding acyl chloride. The reaction is catalyzed by a suitable base such as triethylamine. High yields and good selectivity are achieved under anhydrous conditions, which is crucial for the successful synthesis of this compound.

What industries use (3R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-piperidinecarboxylic acid (CAS: 193693-67-3)?

(3R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-piperidinecarboxylic acid is primarily used in pharmaceutical and polymer industries. Its unique chemical structure makes it a valuable intermediate for the synthesis of various drugs and polymers that require specific functional groups. Additionally, it may find applications in sensor and semiconductor technologies due to its reactivity and structural complexity.

What precautions should be taken when handling (3R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-piperidinecarboxylic acid (CAS: 193693-67-3)?

When handling (3R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-piperidinecarboxylic acid, it is essential to use appropriate personal protective equipment (PPE) such as gloves, safety glasses, and lab coat. This compound should be handled in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately with appropriate absorbent materials, and the area should be flushed with water. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.