3-Hydroxy-2-piperidinone

Basic Information

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CAS Number

19365-08-3

Molecular Formula

C5H9NO2

Molecular Weight

115.13 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Boiling Point

352.3°C at 760 mmHg

Density

1.199

Flash Point

166.8°C

Refractive Index

1.497

SMILES

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C1CC(C(=O)NC1)O

InChI

InChI=1S/C5H9NO2/c7-4-2-1-3-6-5(4)8/h4,7H,1-3H2,(H,6,8)

InChIKey

RYKLZUPYJFFNRR-UHFFFAOYSA-N

LogP

-0.7427000000000001

Topological Polar Surface Area

49.33 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

103

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

MFCD00023163
AKOS006274551
3-hydroxy-2-piperidinone
SY110845
NSC100722
3-Hydroxy-2-piperidone
(3S)-3-Hydroxy-2-piperidinone
SILVERMETHANESULFONATE
19365-08-3
FT-0650422
NSC 100722
A854115
SB41293
3-hydroxypiperidin-2-one
J-512627
DTXSID50295242
NSC-100722
J-502452
(3R)-3-Hydroxy-2-piperidinone
RYKLZUPYJFFNRR-UHFFFAOYSA-N
CS-W008630
SCHEMBL2785455
2-Piperidinone, 3-hydroxy-
SB23117
GS-3884
3-hydroxy-piperidin-2-one
EN300-126596
CHEMBL4535577
SB23118
3-Hydroxypiperidin-2-one
2-Piperidinone,3-hydroxy-

MDL Number

MFCD00023163

Customs Code

2933790090

FAQ

What are the physical and chemical properties of 3-Hydroxy-2-piperidinone (CAS: 19365-08-3)?

3-Hydroxy-2-piperidinone (CAS: 19365-08-3) is a crystalline compound with a molecular weight of approximately 116.15 g/mol. It has a slightly bitter taste and is soluble in water and organic solvents. This compound is moderately reactive, particularly towards nucleophiles and reducing agents.

How is 3-Hydroxy-2-piperidinone (CAS: 19365-08-3) typically synthesized?

3-Hydroxy-2-piperidinone is typically synthesized via the Michael addition of acrylonitrile to 2-piperidone, followed by hydrolysis. The reaction is catalyzed by an acid or base, and the process yields the target compound with good selectivity and a high yield.

What industries use 3-Hydroxy-2-piperidinone (CAS: 19365-08-3)?

3-Hydroxy-2-piperidinone (CAS: 19365-08-3) is used in the pharmaceutical industry for the synthesis of certain drugs, as well as in polymer production for its ability to improve the properties of polymer matrices. It also finds applications in the chemical sensor industry for its reactivity.

What precautions should be taken when handling 3-Hydroxy-2-piperidinone (CAS: 19365-08-3)?

When handling 3-Hydroxy-2-piperidinone (CAS: 19365-08-3), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to avoid inhalation. Spills should be cleaned up immediately, and the Safety Data Sheet (SDS) should be consulted for detailed instructions on disposal and emergency procedures.