[4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](2-furyl)methanone

Basic Information

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CAS Number

19216-56-9

Molecular Formula

C19H21N5O4

Molecular Weight

383.41 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

278-280 ºC

Boiling Point

638.366°C at 760 mmHg

Flash Point

339.9°C

Refractive Index

1.7600 (estimate)

SMILES

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COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC=CO4)N)OC

InChI

InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22)

InChIKey

IENZQIKPVFGBNW-UHFFFAOYSA-N

LogP

1.7845999999999997

Topological Polar Surface Area

106.95 Å²

Hydrogen Bond Donor/Acceptor

2 / 9

Complexity

544

Synonyms & References

English

Bio2_000358
Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)- (9CI)
[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl](furan-2-yl)methanone
NCGC00016740-18
2-(4-(2-FUROYL)-1-PIPERAZINYL)-6,7-DIMETHOXY-4-QUINAZOLINAMINE
C07368
[3H]-Furazosin
BSPBio_002221
Q425296
KBioGR_000376
AB00053528-19
KBio3_000731
C02CA01
NCGC00016740-19
Tox21_113646_1
2-[4-(furan-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine
2-[4-(2-furoyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine
prazosin
Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)-
GTPL5385
KBio2_006438
Spectrum2_001289
DTXCID0029008
Spectrum_000822
W-107722
L000666
NCGC00016740-13
Oprea1_314778
KBio2_003870
EN300-229477
UNII-XM03YJ541D

MDL Number

MFCD00599563

Customs Code

2934999090

FAQ

What are the physical and chemical properties of [4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](2-furyl)methanone (CAS: 19216-56-9)?

The compound [4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](2-furyl)methanone (CAS: 19216-56-9) is a crystalline solid with a molecular weight of approximately 487.4 g/mol. It is slightly soluble in water but more soluble in organic solvents like dimethylformamide and ethanol. The compound is reactive towards nucleophiles and bases. It also exhibits spectroscopic properties typical of quinazolines and piperazines.

How is [4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](2-furyl)methanone (CAS: 19216-56-9) typically synthesized?

The compound [4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](2-furyl)methanone (CAS: 19216-56-9) is typically synthesized via multistep reactions involving the condensation of 4-(4-amino-6,7-dimethoxy-2-quinazolinyl)piperazine with 2-furaldehyde. Commonly, this involves using sodium ethoxide as a base and ethanol as a solvent. The reaction is carried out under mild conditions to ensure high yield and selectivity.

What industries use [4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](2-furyl)methanone (CAS: 19216-56-9)?

The compound [4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](2-furyl)methanone (CAS: 19216-56-9) is used in pharmaceuticals for developing novel drugs, as well as in the sensor industry for its reactivity towards specific analytes. It also finds applications in the semiconductor industry due to its electronic properties.

What precautions should be taken when handling [4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](2-furyl)methanone (CAS: 19216-56-9)?

When handling [4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](2-furyl)methanone (CAS: 19216-56-9), it is essential to wear gloves, goggles, and a lab coat to protect from skin and eye contact. The container must be stored in a well-ventilated area, and work should be carried out in a fume hood. In case of spills, neutralize with an appropriate reagent before cleaning up. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.