3,6-Dichloro-4-methylpyridazine

Basic Information

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CAS Number

19064-64-3

Molecular Formula

C5H4Cl2N2

Molecular Weight

163.01 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

Pale-yellow to Yellow-brown Solid

Melting Point

85.0 to 89.0 deg-C

Boiling Point

151°C/21mmHg

Flash Point

149-151℃/21mm

Refractive Index

1.6300 (estimate)

SMILES

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CC1=CC(=NN=C1Cl)Cl

InChI

InChI=1S/C5H4Cl2N2/c1-3-2-4(6)8-9-5(3)7/h2H,1H3

InChIKey

ROYHWGZNGMXQEU-UHFFFAOYSA-N

LogP

2.09182

Topological Polar Surface Area

25.78 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

MFCD00006465
AKOS002664409
FT-0614753
NCIOpen2_000190
CS-W016104
4-methyl-3,6-dichloropyridazine
PB23168
Pyridazine, 3,6-dichloro-4-methyl-
3,6-Dichloro-4-methylpyridazine
Pyridazine,6-dichloro-4-methyl-
NSC-66367
NS00026231
SY011916
19064-64-3
DTXSID10172560
A4202
W-200190
NSC66367
GEO-00993
SCHEMBL103039
3,6-Dichloro-4-methyl-pyridazine
3,6-Dichloro-5-methylpyridazine
AM20090113
3,6-Dichloro-4-methylpyridazine, 97%
HY-W015388
AC-1777
EINECS 242-794-3
5XGB6YT2PH
FT-0646975
NSC 66367
Z1203161864

MDL Number

MFCD00006465

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 3,6-Dichloro-4-methylpyridazine (CAS: 19064-64-3)?

3,6-Dichloro-4-methylpyridazine (CAS: 19064-64-3) is a crystalline solid with a molecular weight of approximately 174.06 g/mol. It has a melting point of around 190-195°C. The compound is slightly soluble in water but soluble in common organic solvents like ethanol and acetone. It is reactive towards nucleophiles and exhibits electrophilic aromatic substitution reactivity.

How is 3,6-Dichloro-4-methylpyridazine (CAS: 19064-64-3) typically synthesized?

3,6-Dichloro-4-methylpyridazine can be synthesized via the reaction of 4-methylpyridine with chlorine in the presence of a Lewis acid catalyst, such as aluminum chloride. The reaction is selective and provides good yield under mild conditions. The process involves electrophilic aromatic substitution and results in the introduction of chloro substituents at the 3 and 6 positions.

What industries use 3,6-Dichloro-4-methylpyridazine (CAS: 19064-64-3)?

3,6-Dichloro-4-methylpyridazine (CAS: 19064-64-3) is used in various industries, particularly in pharmaceuticals for the synthesis of certain drugs. It is also employed in the production of pesticides, dyes, and as an intermediate in the synthesis of polymeric materials and sensors. Its application in semiconductors is less common but possible depending on the specific structural requirements.

What precautions should be taken when handling 3,6-Dichloro-4-methylpyridazine (CAS: 19064-64-3)?

When handling 3,6-Dichloro-4-methylpyridazine (CAS: 19064-64-3), it is important to use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up using appropriate absorbents and disposed of according to local regulations. Always refer to the Material Safety Data Sheet (MSDS) or Safety Data Sheet (SDS) for detailed safety information.