2,4-Dichlorothieno[2,3-d]pyrimidine | CAS No. 18740-39-1

Q: What are the physical and chemical properties of 2,4-Dichlorothieno[2,3-d]pyrimidine (CAS: 18740-39-1)?

2,4-Dichlorothieno[2,3-d]pyrimidine is a crystalline solid with a molecular weight of approximately 219.03 g/mol. It has a low solubility in water but is more soluble in organic solvents such as ethanol and acetone. Chemically, it is relatively unreactive under normal conditions but can undergo substitution reactions under certain conditions. It is stable under normal storage conditions but should be handled with care, especially when exposed to strong reducing agents.

Q: How is 2,4-Dichlorothieno[2,3-d]pyrimidine (CAS: 18740-39-1) typically synthesized?

2,4-Dichlorothieno[2,3-d]pyrimidine can be synthesized via the condensation of 2,4-dichlorothiophene with 2,3-diaminopyrimidine. The reaction is typically carried out in the presence of an acid catalyst, such as sulfuric acid, with a yield of about 70-80%. The reaction is selective and the product is isolated by crystallization from an appropriate solvent.

Q: What industries use 2,4-Dichlorothieno[2,3-d]pyrimidine (CAS: 18740-39-1)?

2,4-Dichlorothieno[2,3-d]pyrimidine is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various drugs. It is also used in the polymer industry for the development of novel materials and in the semiconductor industry for the production of electronic materials. Additionally, it may be used in the production of sensors and other specialized applications.

Q: What precautions should be taken when handling 2,4-Dichlorothieno[2,3-d]pyrimidine (CAS: 18740-39-1)?

When handling 2,4-Dichlorothieno[2,3-d]pyrimidine, ensure safety gloves, goggles, and a lab coat are worn. Work in a well-ventilated area or fume hood to minimize exposure. Store the compound in a cool, dry place away from direct sunlight. Spills should be handled by neutralizing the material with an appropriate agent before disposal. Always refer to the Material Safety Data Sheet (MSDS) for specific safety guidelines and emergency procedures.

2,4-Dichlorothieno[2,3-d]pyrimidine

Basic Information

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CAS Number

18740-39-1

Molecular Formula

C6H2Cl2N2S

Molecular Weight

205.07 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

Solid

SMILES

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C1=CSC2=C1C(=NC(=N2)Cl)Cl

InChI

InChI=1S/C6H2Cl2N2S/c7-4-3-1-2-11-5(3)10-6(8)9-4/h1-2H

InChIKey

HRXNGIQKOWQHCX-UHFFFAOYSA-N

LogP

2.9981

Topological Polar Surface Area

25.78 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

158

Safety Information

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Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class 6.1 Class 6.1

Synonyms & References

English

AS-18183
PB20371
CS-W003631
18740-39-1
2,4-bis(chloranyl)thieno[2,3-d]pyrimidine
FT-0646970
2,4-dichloro-thieno[2,3-d]pyrimidine
A4146
BCP26750
AKOS005146066
AM20090094
2,4-Dichlorothieno[2,3-d]pyrimidine, AldrichCPR
SY007978
SCHEMBL1182070
THIENO[2,3-D]PYRIMIDINE, 2,4-DICHLORO-
Z1148267341
EN300-72514
DTXSID20480926
A813147
dichlorothieno[2,3-d]pyrimidine
HRXNGIQKOWQHCX-UHFFFAOYSA-N
2,4-Dichlorothieno[2,3-d]pyrimidine
MFCD09743991
W-206366
2,4-dichlorothieno[2,3-d]pyrimidine
2,4-Dichloro-thieno[2,3-d]pyrimidine
2,4,5-TRIMETHYL-3-OXAZOLINE
2,4-dichlorothieno<2,3-d>pyrimidine
2,4-Dichlor-thieno<pyrimidin
QC-152
2,4-Dichlorothieno[2,3-d]...

MDL Number

MFCD09743991

Customs Code

2934999090

FAQ

What are the physical and chemical properties of 2,4-Dichlorothieno[2,3-d]pyrimidine (CAS: 18740-39-1)?

2,4-Dichlorothieno[2,3-d]pyrimidine is a crystalline solid with a molecular weight of approximately 219.03 g/mol. It has a low solubility in water but is more soluble in organic solvents such as ethanol and acetone. Chemically, it is relatively unreactive under normal conditions but can undergo substitution reactions under certain conditions. It is stable under normal storage conditions but should be handled with care, especially when exposed to strong reducing agents.

How is 2,4-Dichlorothieno[2,3-d]pyrimidine (CAS: 18740-39-1) typically synthesized?

2,4-Dichlorothieno[2,3-d]pyrimidine can be synthesized via the condensation of 2,4-dichlorothiophene with 2,3-diaminopyrimidine. The reaction is typically carried out in the presence of an acid catalyst, such as sulfuric acid, with a yield of about 70-80%. The reaction is selective and the product is isolated by crystallization from an appropriate solvent.

What industries use 2,4-Dichlorothieno[2,3-d]pyrimidine (CAS: 18740-39-1)?

2,4-Dichlorothieno[2,3-d]pyrimidine is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various drugs. It is also used in the polymer industry for the development of novel materials and in the semiconductor industry for the production of electronic materials. Additionally, it may be used in the production of sensors and other specialized applications.

What precautions should be taken when handling 2,4-Dichlorothieno[2,3-d]pyrimidine (CAS: 18740-39-1)?

When handling 2,4-Dichlorothieno[2,3-d]pyrimidine, ensure safety gloves, goggles, and a lab coat are worn. Work in a well-ventilated area or fume hood to minimize exposure. Store the compound in a cool, dry place away from direct sunlight. Spills should be handled by neutralizing the material with an appropriate agent before disposal. Always refer to the Material Safety Data Sheet (MSDS) for specific safety guidelines and emergency procedures.