8-Quinolinesulfonyl chloride

Basic Information

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CAS Number

18704-37-5

Molecular Formula

C9H6ClNO2S

Molecular Weight

227.67 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

126-129 °C <br />126-129 °C

Boiling Point

355.9°C at 760 mmHg

Density

1.4830

Flash Point

306°C

Solubility

methanol: soluble10mg/mL, clear, colorless to light yellow

Refractive Index

1.535

SMILES

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C1=CC2=C(C(=C1)S(=O)(=O)Cl)N=CC=C2

InChI

InChI=1S/C9H6ClNO2S/c10-14(12,13)8-5-1-3-7-4-2-6-11-9(7)8/h1-6H

InChIKey

JUYUYCIJACTHMK-UHFFFAOYSA-N

LogP

2.1623

Topological Polar Surface Area

47.03 Å²

Hydrogen Bond Donor/Acceptor

0 / 3

Complexity

298

Safety Information

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GHS Hazard Pictograms

H314

Hazard Statement

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

Hazard Class

Class 8 Class 8

Sensitiveness

Moisture Sensitive

Synonyms & References

English

QUINOLINESULFONYL CHLORIDE, 8-
8-chlorosulfonylquinoline
NSC 91506
8-Chlorosulfonyl-1-benzazine
Q27263105
18704-37-5
BB 0254509
J-012029
8-quinoline sulfonylchloride
SCHEMBL51046
UNII-5ZIK3TJS9M
8-Quinolylsulfonyl chloride
AM803421
SB40802
EINECS 242-515-5
CS-W014696
Quinoline-8-sulfonic acid chloride
FT-0637739
J-519474
8-Quinolinesulphonyl chloride
NSC-91506
Quinoline-8-sulfonyl choride
A813103
8-quinolinyl sulfonyl chloride
8-quinolinylsulfonyl chloride
Quinoline-8-sulfonyl chloride
AKOS000309929
DTXSID90171975
Quinoline-8-sulphonyl chloride
8-Quinolinesulfonyl chloride, >=96.0% (AT)
8-Quinoline sulfonyl chloride

MDL Number

MFCD00006808

Customs Code

29334990

FAQ

What are the physical and chemical properties of 8-Quinolinesulfonyl chloride (CAS: 18704-37-5)?

8-Quinolinesulfonyl chloride (CAS: 18704-37-5) is a white crystalline solid with a molecular weight of approximately 236.04 g/mol. It has low solubility in water but is more soluble in organic solvents like methanol and ethanol. Chemically, it is highly reactive and susceptible to hydrolysis in the presence of moisture. It is used as a precursor in the synthesis of various pharmaceutical and chemical intermediates.

How is 8-Quinolinesulfonyl chloride (CAS: 18704-37-5) typically synthesized?

8-Quinolinesulfonyl chloride is typically synthesized by reacting 8-quinolinesulfonic acid with thionyl chloride. The reaction proceeds under anhydrous conditions to avoid hydrolysis, providing a high yield of the desired product with good selectivity. The process can be optimized with the use of a phase transfer catalyst to improve product purity and yield.

What industries use 8-Quinolinesulfonyl chloride (CAS: 18704-37-5)?

8-Quinolinesulfonyl chloride (CAS: 18704-37-5) is primarily used in the pharmaceutical industry as a precursor for the synthesis of certain active pharmaceutical ingredients. It is also utilized in the polymer industry for the modification of polymer properties, and in the electronic industry for the production of sensors and semiconductors.

What precautions should be taken when handling 8-Quinolinesulfonyl chloride (CAS: 18704-37-5)?

When handling 8-Quinolinesulfonyl chloride (CAS: 18704-37-5), it is important to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and lab coats. This compound should be stored in a cool, dry place and handled within a well-ventilated fume hood to avoid contact with moisture. In case of spillage, it should be cleaned up immediately using appropriate absorbent materials and reported to a safety officer. Refer to the Material Safety Data Sheet (MSDS) for detailed instructions and safety precautions.