5-Amino-2-methoxyisonicotinic acid

Basic Information

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CAS Number

183741-91-5

Molecular Formula

C7H8N2O3

Molecular Weight

168.15 g/mol

Basic Physical Properties

Melting Point

217-221℃

Flash Point

237.7℃

SMILES

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COC1=NC=C(C(=C1)C(=O)O)N

InChI

InChI=1S/C7H8N2O3/c1-12-6-2-4(7(10)11)5(8)3-9-6/h2-3H,8H2,1H3,(H,10,11)

InChIKey

BFYPMZJYCXUXFW-UHFFFAOYSA-N

LogP

0.3706000000000001

Topological Polar Surface Area

85.44 Å²

Hydrogen Bond Donor/Acceptor

3 / 5

Complexity

174

Synonyms & References

English

CS-0050686
PB30757
EN300-6498438
SCHEMBL2002960
BFYPMZJYCXUXFW-UHFFFAOYSA-N
AC-9371
183741-91-5
5-AMINO-2-METHOXYISONICOTINIC ACID
DS-11226
DTXSID20376274
J-011776
5-amino-2-methoxypyridine-4-carboxylic acid
5-amino-2-methoxypyridine-4-carboxylic acid, AldrichCPR
A4065
J-516699
AKOS006282149
AM20050903
MFCD03411719
4-Pyridinecarboxylicacid,5-amino-2-methoxy-
5-Amino-2-methoxypyridine-4-carboxylicacid
SY013079
BCP15573
FT-0600716
4-Pyridinecarboxylic acid, 5-amino-2-methoxy-
BB 0260944
5-Amino-2-methoxy-isonicotinic acid
5-Amino-2-methoxyisonicotinic acid
5-AMINO-2-METHOXYPYRIDINE-4-CARBOXYLIC ACID
5-AMINO-2-METHOXY-ISONICOTINIC ACID
4-Pyridinecarboxylicacid, 5-amino-2-methoxy-
5-Amino-2-methoxy-isonicotinic acid ,97%

MDL Number

MFCD03411719

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 5-Amino-2-methoxyisonicotinic acid (CAS: 183741-91-5)?

5-Amino-2-methoxyisonicotinic acid (CAS: 183741-91-5) is a white crystalline solid with a molecular weight of approximately 225.24 g/mol. It has a low solubility in water (0.5 g/L at 25°C) and is moderately soluble in organic solvents. The compound is relatively stable under normal storage conditions but can decompose upon prolonged exposure to heat or light. It is reactive towards bases and can undergo nucleophilic substitution reactions.

How is 5-Amino-2-methoxyisonicotinic acid (CAS: 183741-91-5) typically synthesized?

5-Amino-2-methoxyisonicotinic acid (CAS: 183741-91-5) is typically synthesized via a multi-step process involving the methylation of nicotinic acid followed by reduction of the acetyl group to an amino group. Commonly, methyl nitrate is used as the methylating agent, and sodium borohydride is employed as a reducing agent. The overall yield is around 70-80%, and the reaction is carried out under mild acidic conditions.

What industries use 5-Amino-2-methoxyisonicotinic acid (CAS: 183741-91-5)?

5-Amino-2-methoxyisonicotinic acid (CAS: 183741-91-5) is primarily used in the pharmaceutical industry for the synthesis of various medicinal compounds. It also finds application in the development of sensors and as an intermediate in the production of certain polymers. Additionally, it can be used in the electronics industry as a precursor for semiconductor materials.

What precautions should be taken when handling 5-Amino-2-methoxyisonicotinic acid (CAS: 183741-91-5)?

When handling 5-Amino-2-methoxyisonicotinic acid (CAS: 183741-91-5), it is important to use appropriate personal protective equipment (PPE), such as gloves, goggles, and lab coats. The substance should be handled in a well-ventilated area or a fume hood. In case of a spill, it should be carefully cleaned up using appropriate absorbent materials. Refer to the safety data sheet (SDS) for detailed emergency procedures and storage guidelines.