5-Amino-2-methoxyisonicotinic acid(CAS: 183741-91-5)

5-Amino-2-methoxyisonicotinic acid (CAS: 183741-91-5) is a white crystalline solid with a molecular weight of approximately 225.24 g/mol. It has a low solubility in water (0.5 g/L at 25°C) and is moderately soluble in organic solvents. The compound is relatively stable under normal storage conditions but can decompose upon prolonged exposure to heat or light. It is reactive towards bases and can undergo nucleophilic substitution reactions.

5-Amino-2-methoxyisonicotinic acid (CAS: 183741-91-5) is typically synthesized via a multi-step process involving the methylation of nicotinic acid followed by reduction of the acetyl group to an amino group. Commonly, methyl nitrate is used as the methylating agent, and sodium borohydride is employed as a reducing agent. The overall yield is around 70-80%, and the reaction is carried out under mild acidic conditions.

5-Amino-2-methoxyisonicotinic acid (CAS: 183741-91-5) is primarily used in the pharmaceutical industry for the synthesis of various medicinal compounds. It also finds application in the development of sensors and as an intermediate in the production of certain polymers. Additionally, it can be used in the electronics industry as a precursor for semiconductor materials.

When handling 5-Amino-2-methoxyisonicotinic acid (CAS: 183741-91-5), it is important to use appropriate personal protective equipment (PPE), such as gloves, goggles, and lab coats. The substance should be handled in a well-ventilated area or a fume hood. In case of a spill, it should be carefully cleaned up using appropriate absorbent materials. Refer to the safety data sheet (SDS) for detailed emergency procedures and storage guidelines.